Intracellular acidosis via activation of Akt-Girdin signaling promotes post ischemic angiogenesis during hyperglycemia

The impaired angiogenesis is the major cause of diabetic delayed wound healing. The molecular insight remains unknown. Previous study has shown that high glucose (HG) activates Na+/H+ exchanger 1 (NHE1) and induces intracellular alkalinization, resulting in endothelial dysfunction. The aim of this study is to investigate whether activation of NHE1 in endothelial cells by HG damages the angiogenesis in vitro and in vivo.

Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Hong-Ming Zhang, Mo-Yan Liu, Jun-Xiu Lu, Mo-Li Zhu, Qun Jin, Song Ping, Peng Li, Xu Jian, Ya-Ling Han, Shuang-Xi Wang, Xiao-Yan Li Source Type: research