Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis [Neuroscience]

Regulated exocytosis, which underlies many intercellular signaling events, is a tightly controlled process often triggered by calcium ion(s) (Ca2+). Despite considerable insight into the central components involved, namely, the core fusion machinery [soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE)] and the principal Ca2+ sensor [C2-domain proteins like synaptotagmin (Syt)], the...

Source: Proceedings of the National Academy of Sciences - August 7, 2018 Category: Science Authors: Oscar D. Bello, Ouardane Jouannot, Arunima Chaudhuri, Ekaterina Stroeva, Jeff Coleman, Kirill E. Volynski, James E. Rothman, Shyam S. Krishnakumar Tags: PNAS Plus Source Type: research