Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking.
Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking. Behav Brain Res. 2018 Aug 02;: Authors: Fitzpatrick CJ, Jagannathan L, Lowenstein E, Robinson TE, Becker JB, Morrow JD Abstract Exposure to prolonged, uncontrollable stress reduces reward-seeking behavior, resulting in anhedonia in neuropsychiatric disorders, such as posttraumatic stress disorder. However, it is unclear to what degree stressed subjects lose interest in rewards themselves or in reward-related cues that instigate reward-seeking behavior. In the present study, we investigated the effects of single prolonged stress (SPS) on cue-directed behavior in two different procedures: Pavlovian conditioned approach (PCA) and cue-induced reinstatement of cocaine-seeking. In Experiment 1, rats were exposed to SPS and tested for the acquisition of sign-tracking (cue-directed) and goal-tracking (reward-directed) behaviors during a PCA procedure. In Experiment 2, rats were exposed to SPS and tested for the expression of sign- and goal-tracking as well as cue-induced reinstatement of cocaine-seeking. Because dopaminergic activity in the nucleus accumbens is known to play a central role in many cue-directed behaviors, including both sign-tracking and cue-induced reinstatement, Experiment 3 used in vivo microdialysis to measure the effect of SPS on baseline and evoked dopamine levels in the nucleus accumbens. SPS decreased sign-tracking and increased goal-tracking...
Conclusion: Based on these results NDDS is considered to be an applicable instrument for identifying personality pathology in patients with depressive symptoms, by recognizing the specific pattern. This is thought to be important for adequate treatment planning. PMID: 31517547 [PubMed - as supplied by publisher]
The conversations -- all with college students between 18 and 21 -- give anecdotal looks into how the nicotine-addicted are dealing with what officials have called a public health crisis.
A 10-year-old girl is fighting for her life after she contracted a brain-eating amoeba after swimming in the Brazos River and Lake Whitney in Bosque County near Waco, Texas.
Don't do it. Please don't do it.
WHEN celebrated artist Alison Lapper began making plans for her wedding, her dream was for her son Parys to give her away.
[And we've reached the 50th Anniversary of Revista Argentina de Microbiología]. Rev Argent Microbiol. 2019 Jul - Sep;51(3):189-190 Authors: Di Conza JA, Predari SC PMID: 31514958 [PubMed - in process]
I am a big fan of Prue Leith, 79, pictured, and have no doubt her knowledge of souffles is unsurpassed, I'm not sure if the same can be said of her medical experience, writes EVE SIMMONS.
PMID: 31514692 [PubMed - in process]
As a child born in 2018, my little girl has a one in three chance of living to 100. In contrast, as someone born in 1917, Pamela would have been considered lucky to live past 60.
CONCLUSIONS Our results demonstrated a regulation loop among MATAL1, miR-194, and YAP1, which dynamically regulates the progression of AP, providing a new therapeutic target for treatment of this disease. PMID: 31518341 [PubMed - in process]