Direct Activation of the Large-Conductance Calcium-Activated Potassium Channel by Flavonoids Isolated from Sophora flavescens.

Direct Activation of the Large-Conductance Calcium-Activated Potassium Channel by Flavonoids Isolated from Sophora flavescens. Biol Pharm Bull. 2018;41(8):1295-1298 Authors: Lee S, Choi JS, Park CS Abstract In our recent study, we reported that kurarinone, one of the most abundant flavonoids found in the dry root of Sophora flavescens (Kushen), is a potent activator of the large-conductance Ca2+-activated K+ (BKCa) channel. Herein, we isolated and characterized other flavonoid components from Kushen. Among the 13 compounds tested, six flavonoids were found to activate the BKCa channel, three of which, 7,4'-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone, kuraridin, and kuraridinol, are new activators of the BKCa channel. PMID: 30068881 [PubMed - in process]
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research