OUTCOMES OF PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION TREATED WITH ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR THREE OR MORE YEARS: A Review of Current Outcomes

Conclusion: The body of evidence to date regarding long-term anti-VEGF treatment indicates a variable course at greater than 36 months follow-up and seems to be dependent on the treatment protocol. Consistent dosing with fluid-free interval is suggested to maintain VA gains in patients with exudative age-related macular degeneration. There is no evidence suggesting that there are additional adverse events from long-term anti-VEGF use.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research

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Publication date: Available online 14 September 2019Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Noémie Schwob, Anja Palmowski-WolfeAbstractPurposeTo investigate the correlation between subjective and objective visual acuity as elicited with a new computerized optokinetic nystagmus (OKN) suppression test (“SpeedWheel”) in adults and school-aged children.MethodsFifteen children (6-12 years) and 27 adults with refractive errors, amblyopia, cataract, age-related macular degeneration, and thyroid-associated orbitopathy underwent testing of subjective visual acu...
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionThe qualitative results revealed that older adults living with visual impairment develop strategies to improve their quality of life and help them age in place.
Source: Age and Ageing - Category: Geriatrics Source Type: research
Authors: Chatard H, Tepenier L, Beydoun T, Offret O, Salah S, Sahel JA, Mohand-Said S, Bucci MP Abstract OBJECTIVE: To compare the impact of unilateral versus bilateral age-related macular degeneration (AMD) on saccadic movements, and to show the effect of visual search training on these eye movement performances in AMD subjects. We hypothesized that unilateral and bilateral AMD subjects had abnormal saccadic performances, and that visual search training could improve their performances. METHODS: Three groups participated in visual search training: 13 elderly unilateral AMD subjects (mean age: 74.6 ± 1.6...
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
Authors: Hussain RM, Neiweem AE, Kansara V, Harris A, Ciulla TA Abstract Introduction: The Tie-2/Angiopoietin pathway is therapeutic target in neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). Activation of Tie-2 receptor via Ang-1 maintains vascular stability to limit exudation. Ang-2, a competitive antagonist to Ang-1, and VE-PTP, an endothelial-specific phosphatase, interfere with the Tie-2-Ang-1 axis, resulting in vascular leakage. Areas Covered: Faricimab, a bispecific antibody that inhibits VEGF-A and Ang-2, is in phase 3 trials for nAMD and DME. Nesvacumab is an Ang-2 inhi...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
To compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes using projection-resolved optical coherence tomography angiography (PR-OCTA).
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
This article discusses the rationale for the use of certain ingredients of AREDS supplements and critically examines the results of AREDS. Furthermore, the modern term "lifestyle" will be discussed in the context of AMD as a possibility to influence the progression of this disease. PMID: 31509858 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Authors: Fleckenstein M, Thiele S, Pfau M, Schmitz-Valckenberg S, Holz FG Abstract Age-related macular degeneration (AMD) is clinically divided into early and late stages. The term "dry" AMD is widely used when there are no "exudative" changes in the ocular fundus. There are numerous studies on the epidemiology of AMD. Most studies differentiate between early and late forms of AMD, but without further differentiation of the "dry" late form. In addition, different studies may employ different classifications of AMD, which inevitably leads to deviations in epidemiological data on AMD. Ne...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Authors: Joussen AM, Helbig H PMID: 31509856 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Conditions:   Age-related Macular Degeneration;   Coronary Artery Disease;   Cardiovascular Diseases Intervention:   Genetic: Blood draw Sponsor:   The New York Eye & Ear Infirmary Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The use of nanomaterials is an emerging therapeutic approach for the treatment of several pathologies. Cerium oxide nanoparticles have been studied for biomedical application, including neurodegenerative disorders, such as age-related macular degeneration in several animal models. The light damage model is characterised by oxidative stress upregulation followed by photoreceptor death and microglia activation in the outer retina. For this reason, the light damage model mimics some aspects involved in human age-related macular degeneration pathogenesis. In this review, we focus on the neuroprotective effect...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
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