Rapid Improvement of Dilated Cardiomyopathy With Anakinra

TUESDAY, July 31, 2018 -- In a report published online July 31 in the Annals of Internal Medicine, doctors describe the case of a patient with dilated cardiomyopathy who experienced rapid clinical improvements with use of anakinra, the recombinant...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Heart failure (HF) with reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to adequately meet bodily demands, resulting in high mortality despite the current standard of care. In modern societies, the most common drivers of HF are ischemic heart disease and hypertension. However, in a substantial subset of cases, patients present with dilated and poorly contracting hearts without evidence of common inciting stressors, a syndrome called dilated cardiomyopathy (DCM). Genome sequencing has identified a host of deleterious germline variants in key cardiomyocyte genes as causes of ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We report that deletion of Lmna in cardiomyocytes in mice leads to severe cardiac dysfunction, conduction defect, ventricular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks. The phenotype is similar to LMNA-associated cardiomyopathy in humans. RNA sequencing, performed before the onset of cardiac dysfunction, led to identification of 2338 differentially expressed genes (DEGs) in Lmna-deleted cardiomyocytes. DEGs predicted activation of bromodomain-containing protein 4 (BRD4), a regulator of chromatin-associated proteins and transcription factors, which was confirmed by complementary approaches, includ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract Organ transplant from donors with ventricular assist devices is not common. Here, we report organ retrieval from a donor with a left ventricular assist device who had been on the heart transplant wait list before a brain death diagnosis. The organ donor was diagnosed with dilated cardiomyopathy and underwent left ventricular assist device surgery for bridging to heart transplant in 2016. Brain death occurred 22 months after implantation of the device at the age of 39 years due to widespread intraparenchymal and subarachnoid hemorrhage. Brain death diagnosis was confirmed with brain perfusion single-photon...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Publication date: Available online 5 August 2020Source: The Annals of Thoracic SurgeryAuthor(s): Shahnawaz Amdani, Gerard Boyle, Saarel Elizabeth, Justin Godown, Wei Liu, Sarah Worley, Tara Karamlou
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractBackgroundTachycardia-induced cardiomyopathy (TCM) has been known for decades as a  reversible form of non-ischemic cardiomyopathy. However, its mechanism and characteristics remain poorly understood.ObjectivesThis retrospective study investigated endomyocardial biopsy (EMB) samples from consecutive patients with TCM and compared them with samples from patients with dilated cardiomyopathy (DCM) and inflammatory cardiomyopathy (InCM).Materials and methodsA total of 684 patients (18  TCM, 170 DCM, 496 InCM) with recent-onset heart failure and reduced ejection fraction unrelated to valvular or ischemic heart...
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
AimsThe prevalence and hospitalizations of patients with heart failure (HF) aged
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
This study identified IDI2-AS1 and XIST lncRNAs and related pathways involved in the pathogenesis of DCM, thus providing potential diagnostic and therapeutic targets for DCM. PMID: 32727980 [PubMed - as supplied by publisher]
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
We describe the case of an 18‐year‐old male patient, affected by DMD and in a wheelchair from the age of 11. He progressively developed dilated cardiomyopathy, and in 2016, at the age of 14 years, he underwent HeartWare LVAD implantation, as destination therapy, without post‐operative complications. He has been followed up for 47 consecutive months; and 30 months after LVAD implantation, he developed an infection of the exit site, treated by antibiotics and surgical toilette. Following this event, on the basis of patient's good general conditions and willingness, we started to consider heart transplant as a...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
Conclusions: DCM and ICM are considered the most prevalent underlying diseases in heart transplant candidates. Ejection fraction reached normal ranges following transplant, which provides good quality of life. Low incidence of severe acute rejection demonstrates the effectiveness of our immunosuppressive therapy. In the cases of increased rejection, the patient's immunosuppressive regimen was re-assessed accordingly. PMID: 32728361 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
ABSTRACTAimsNon ‐sustained ventricular tachycardia (NSVT) occurs frequently in patients with dilated cardiomyopathy (DCM), especially in high‐risk patients. The role of rapid‐rate NSVT (RR‐NSVT) documented by an implantable cardioverter defibrillator (ICD) in DCM patients has not been fully explored. This s tudy aimed to determine the relationship between RR‐NSVT and the occurrence of ventricular tachyarrhythmias (VTAs) in DCM patients with ICD.MethodsFrom December 2000 to December 2017, 136 DCM patients received ICD or cardiac resynchronization therapy defibrillator (CRT ‐D) implantation for primary or seconda...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ORIGINAL ‐ DEVICE Source Type: research
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