Genetic determinants of vitamin D-related disorders; focus on vitamin D receptor.

Genetic determinants of vitamin D-related disorders; focus on vitamin D receptor. Curr Drug Metab. 2018 Jul 23;: Authors: Abouzid M, Karazniewicz-Lada M, Glowka F Abstract The endocrine system of vitamin D is involved in an extensive variety of biological processes such as bone metabolism, regulation of cell proliferation and differentiation and modulation of the immune response. The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins. Although numerous studies reported polymorphism in the VDR gene, the impact of the polymorphic alleles on VDR protein function remains unknown. BsmI, ApaI, and TaqI are the three adjacent single nucleotide polymorphisms in intron 8/exon nine at the 3' end of the VDR gene which have been most frequently studied so far. Because these polymorphisms are apparently nonfunctional, one or more functional polymorphism elsewhere in the VDR gene, and linkage disequilibrium are expected to explain the association between VDR genes polymorphisms and common diseases. Therefore, the paper focuses on documenting VDR gene polymorphisms and their relationship with vitamin D-related disorders which will increase our understanding of variability in the vitamin D endocrine system and might find applications in disease risk assessment and response-to-treatment prediction. PMID: 30039758 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research