Novel endodontic sealers induced satisfactory tissue response in mice

Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Lea Assed Bezerra da Silva, Amanda Silva Bertasso, Carolina Maschietto Pucinelli, Raquel Assed Bezerra da Silva, Katharina Morant Holanda de Oliveira, Manoel Damião Sousa-Neto, Alberto ConsolaroAbstractObjectivesThe aim of this study was to evaluate the subcutaneous response induced by Roeko Guttaflow2 (RG), Sealapex Xpress (SX), AH Plus (AHP) sealers.Methods100 BALB/c mice received implants in the subcutaneous tissue with the tested materials (10 animals per period for each evaluated sealer) and were evaluated after different experimental periods (7, 21 and 63 days), in each animal was placed a tube, the control group was an empty tube. Histological analysis evaluated semi-quantitatively the inflammatory infiltration, collagen fiber formation and tissue thickness. In addition, immunohistochemistry was performed for interleukin-6 (IL-6). Data were statistically analyzed (α = 0.05).ResultsRG promoted a greater collagen fiber formation at 7 days and 63 days compared to the CG (p = 0.004) and AHP (p = 0.005) respectively, while at 21 days, the SX promoted a greater reaction (p = 0.021). For the tissue thickness, there was a greater reaction at 7 days with CG (p = 0.0156) and with RG at 63 days (p = 0.03). Regarding the inflammatory infiltrate, there was no difference at 7 days and 63 days (p = 0.5; p = 0.27), while at 21 days, a statistically difference was...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research