The Stress Hormone Cortisol Enhances Interferon- υ-Mediated Proinflammatory Responses of Human Immune Cells.

CONCLUSIONS: These results reveal a surprisingly robust proinflammatory interaction between the human stress response hormone cortisol and the immune activating cytokine IFN-υ. The results support an emerging physiological model with an adaptive role for cortisol, wherein acute release of cortisol suppresses early proinflammatory responses but also primes immune cells for an augmented response to a subsequent immune challenge. These findings have broad clinical implications and provide an experimental framework to examine individual differences, mechanisms, and translational implications of cortisol-enhanced immune responses in humans.
PMID: 30028389 [PubMed - in process]

Source: Anesthesia and Analgesia - July 23, 2018 Category: Anesthesiology Authors: Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM Tags: Anesth Analg Source Type: research