The Importance of Bipolar Electrode Orientation on Local Electrogram Properties

Direct impact of bipolar orientation on electrograms remains unknown.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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OBJECTIVES: The suicide crisis is a relatively short-lived psychiatric emergency, with transient symptoms that ebb and flow around the suicide attempt.Understanding the dynamic processes of symptoms before and after suicide attempt may aid future preventio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Publication date: Available online 19 November 2019Source: Journal of Psychiatric ResearchAuthor(s): Beatriz Simões, Evangelos Vassos, Sukhi Shergill, Colm McDonald, Timothea Toulopoulou, Sridevi Kalidindi, Fergus Kane, Robin Murray, Elvira Bramon, Hugo Ferreira, Diana PrataAbstractSchizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illn...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 19 November 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gianna Sepede, Piero Chiacchiaretta, Francesco Gambi, Giuseppe Di Iorio, Domenico De Berardis, Antonio Ferretti, Mauro Gianni Perrucci, Massimo Di Giannantonio
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
AbstractPurpose of ReviewDifferentiating bipolar (BP) disorders (in particular BP II) from borderline personality disorder (BPD) is a common diagnostic dilemma. We sought to critically examine recent studies that considered clinical differences between BP II and BPD, which might advance their delineation.Recent FindingsRecent studies focused on differentiating biological parameters —genetics, epigenetics, diurnal rhythms, structural and functional neuroimaging—with indicative differences not yet sufficient to guide diagnosis. Key differentiating factors include family history, developmental antecedents, illness...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
Publication date: December 2019Source: Results in Physics, Volume 15Author(s): Mohammad Karbalaei, Daryoosh Dideban, Hadi HeidariAbstractThis paper presents the electrical characteristics of a short channel Silicon on Insulator (SOI) transistor with a graphene layer. The graphene sheet is used at the bottom of the channel close to the source side and a proportionally heavily p-type retrograde doping implanted in nearly middle of the channel. To increase the gate electrostatic control over the channel we incorporated a high-K material i.e. HfO2 as the gate oxide insulator. Due to Graphene growth and Retrograde Doping in the...
Source: Results in Physics - Category: Physics Source Type: research
Authors: Yamashita K, Ghafoori E, Silvernagel J, Ashton J, J Dosdall D, MacLeod R, Ranjan R Abstract Radiofrequency (RF) ablation results in creation of acute edema which can lead to temporary disruption of electrical propagation.The goal of this study was to find the effective contact force (CF) to minimize edema formation in comparison to the lesion size.Ventricular RF lesions (n = 49) were created by a CF-sensing catheter in a canine model (n = 10) with varying force for 30 seconds. Animals underwent T2-weighted (T2w) and late gadolinium enhancement MRI (LGE-MRI) immediately after ablation and at 12 weeks. Acute...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
ConclusionsThe presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients ’ HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
The objective of this study was to explore suicidal behavio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
BACKGROUND: Suicide is one of the leading causes of death in bipolar disorder (BD); violent suicide attempts are associated with the highest level of lethality. We aimed to evaluate factors related to the risk of violent suicide in a large naturalistic sam...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Veldink The molecular mechanisms underlying bipolar disorder (BPD) have remained largely unknown. Postmortem brain tissue studies comparing BPD patients with healthy controls have produced a heterogeneous array of potentially implicated protein-coding RNAs. We hypothesized that dysregulation of not only coding, but multiple classes of RNA (coding RNA, long non-coding (lnc) RNA, circular (circ) RNA, and/or alternative splicing) underlie the pathogenesis of BPD. Using non-polyadenylated libraries we performed RNA sequencing in postmortem human medial frontal gyrus tissue from BPD patients and healthy controls. Twenty ge...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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