Enamel anomalies in a pachyonychia congenita patient with a mutation in KRT16

Pachyonychia congenita (PC) is a cutaneous disorder caused by a mutation in the KRT6A, KRT6B, KRT6C, KRT16 or KRT17 genes that encode a subset of epithelial keratins. The main features of the disease are painful palmoplantar keratoderma and variable nail dystrophy. In a recent study, we reported that these keratins are incorporated into mature enamel. Moreover, genetic association study showed that common polymorphisms in KRT6A, KRT6B and KRT6C are associated with increased susceptibility to tooth decay.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research