Synthesis of NSAIDs –Se derivatives as potent anticancer agents

AbstractIn the present study, a series of NSAIDs –Se derivatives include selenocyanates and diselenides were synthesized and characterized, their anticancer activities against the human cancer cell lines SW480, HeLa, A549, and HepG2 were determined. Interestingly, most of the new compounds showed active in reducing the viability of different can cer lines. Compounds1a and1m exhibited higher promising activities than other derivatives. As the most active compound1a showed IC50 values lower than 20  μM against the four cancer cell lines, particularly against SW480 with IC50 values below 10  μm, it shows the potential to be a promising molecular chemotherapeutic agent for colorectal cancer.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research