Sub-3 millimeter, near-200 picosecond TOF/DOI-PET imaging with monolithic scintillator detectors in a 70 cm diameter tomographic setup.

Sub-3 millimeter, near-200 picosecond TOF/DOI-PET imaging with monolithic scintillator detectors in a 70 cm diameter tomographic setup.
Phys Med Biol. 2018 Jul 11;:
Authors: Borghi G, Tabacchini V, Bakker R, Schaart DR
Abstract
Recently, a monolithic scintillator detector for time-of-flight (TOF) / depth-of-interaction (DOI) positron emission tomography (PET) was developed. It has a detector spatial resolution of ~1.7 mm full-width-at-half-maximum (FWHM), a coincidence resolving time (CRT) of ~215 ps FWHM, and ~4.7 mm FWHM DOI resolution. Here, we demonstrate, for the first time, the imaging performance of this detector in a 70 cm diameter PET geometry. We built a tomographic setup representative of a whole-body clinical scanner, comprising two coaxially rotating arms, each carrying a detector module, and a central, rotating phantom table. The fully automated setup sequentially acquires all possible lines of response (LORs) of a complete detector ring, using a step-and-shoot acquisition approach. The modules contained 2 × 2 detectors, each detector consisting of a 32 mm × 32 mm × 22 mm LYSO crystal and a digital silicon photomultiplier (dSiPM) array. The system spatial resolution was assessed using a Na-22 point source at different radial distances in the field-of-view (FOV). Using 2D filtered back projection (2D FBP, non-TOF), tangential and radial spatial resolutions of ~2.9 mm FWHM were obtained at the center of the FOV. The us...

Source: Physics in Medicine and Biology - July 11, 2018 Category: Physics Authors: Borghi G, Tabacchini V, Bakker R, Schaart DR Tags: Phys Med Biol Source Type: research