Low levothyroxine doses during childhood linked to transient congenital hypothyroidism

A study inThyroid suggests that children given a lower dose of levothyroxine were more likely to develop transient congenital hypothyroidism, compared to those on a higher dose.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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ConclusionsThough the available literature is mostly short-term, there is evidence that lithium monotherapy is reasonably safe and effective in children and adolescents, specifically for acute mania and for prevention of mood episodes.
Source: European Psychiatry - Category: Psychiatry Source Type: research
NIH investigators have discovered a series of low molecular weight thyroid-stimulating hormone (TSH) receptor modulators for use in the procedure to detect residual thyroid cancer cells following thyroidectomy. As small molecules, these compounds are orally available and are expected to be less costly and more straightforward to produce than recombinant protein counterparts currently on the market. These compounds appear be orally available, would be less difficult and expensive to produce, and are also more potent and/or specific for the TSH receptor than other known small-molecule TSH receptor agonists. In addition to us...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
We present the first documented case of pembrolizumab-induced grade IV neutropenia. A 73-year-old women known for myositis, Crohn’s disease, and hypothyroidism and diagnosed with PD-L1 positive stage IV pulmonary adenocarcinoma is treated with Pembrolizumab. She develops grade IV neutropenia 2 weeks after her second infusion. She is therefore hospitalized and treated initially with corticosteroids, granulocyte colony-stimulating factor, and intravenous immunoglobulins. Given the persistent neutropenia, cyclosporine was added, but quickly stopped owing to fever. The patient recovered her neutrophils 6.5 weeks after he...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
In this report, we studied the cases with pathologically evident ischemic heart disease (IHD) at autopsy and correlated with absence or presence of thyroid disease. In a five-year retrospective autopsy-based study, cases with IHD in whom the thyroid gland was dissected at autopsy were analyzed. The thyroid gland was available for assessment in 181 of the 255 autopsied cases with IHD. Majority were males with a mean age of 59.9 years. Thyroid pathology was noted in 58 patients (32.0%) in the form of uni-nodular or multinodular goiter (56.9%), lymphocytic thyroiditis (37.9%) and Hashimoto’s thyroiditis (5.2%). Based on...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Thyroid, Ahead of Print.
Source: Thyroid - Category: Endocrinology Authors: Source Type: research
Horm Metab Res DOI: 10.1055/a-0658-2095To investigate the mechanism responsible for the neurological alterations, miRNA expression profile and brain-derived neurotrophic factor (BDNF) were evaluated in brain tissues of fetal or neonatal rats and from maternal rats with hypothyroidism. Ninety female Wistar rats were divided into a control and a hypothyroid group, which were mated. Brain samples of the offspring were obtained at maternal embryonic day (E) E13 and E17 as well as postnatal day (P) P0 and P7, and the hippocampus and cortex were separated at P7. BDNF mRNA at E13 was tested by real-time PCR and protein expression...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Research Source Type: research
A 38-year-old woman with a history of hypothyroidism and allergic conjunctivitis was referred for evaluation of her left upper eyelid after noticing drooping for 2 months, which was confirmed on review of old photographs. What would you do next?
Source: JAMA Facial Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Conclusion: The present case not only illustrates the phenotypic diversity ofDUOXA2 mutation carriers but also implies that DUOXA2 is important in prenatal thyroid hormone production.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
By Sandee LaMotte, CNN (CNN) — Certain batches of hypothyroid medications are being recalled by Westminster Pharmaceuticals after one of its Chinese suppliers failed a US Food and Drug Administration inspection. The medication in question contains a combination of levothyroxine, called LT4, and liothyronine, called LT3. Both are synthetic thyroid hormones used when a person’s thyroid gland is no longer functioning properly. “While we stand behind the quality of our product, we are taking the utmost precaution by recalling our Thyroid, USP Tablets only to the wholesale level due to a recent inspection by t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Thyroid Source Type: news
Condition:   Hypothyroidism Interventions:   Drug: Iohexol;   Drug: Iodixanol;   Drug: Iopromide Sponsors:   GE Healthcare;   Bayer;   Duke Clinical Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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