Low levothyroxine doses during childhood linked to transient congenital hypothyroidism

A study inThyroid suggests that children given a lower dose of levothyroxine were more likely to develop transient congenital hypothyroidism, compared to those on a higher dose.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Valeria Calsolaro, Filippo Niccolai, Giuseppe Pasqualetti, Alessia Maria Calabrese, Antonio Polini, Chukwuma Okoye, Silvia Magno, Nadia Caraccio, Fabio Monzani
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 4 February 2019Source: Practical Radiation OncologyAuthor(s): Nayan Lamba, Marc R. Bussiere, Andrzej Niemierko, Parisa Abedi, Barbara C. Fullerton, Jay S. Loeffler, Kevin S. Oh, Lisa B. Nachtigall, Helen A. ShihAbstractPurposePatients undergoing cranial irradiation are at high risk for development of subsequent pituitary deficiencies. Patients with meningiomas can expect to live many years after treatment and are therefore particularly vulnerable to long-term sequalae of radiation therapy (RT). The purpose of this study was to determine the rates and timing of onset of pituitary dysfuncti...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionWe suggest educating patients and physicians to recognize changes in thyroid function and close monitoring of unclear cases of overt hyperthyroidism.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
An appropriate diagnostic evaluation is essential for the most appropriate treatment to be performed. Currently, macroprolactinemia is the third most frequent cause of non-physiological hyperprolactinemia after drugs and prolactinomas. Up to 40% of macroprolactinemic patients may present with hypogonadism symptoms, infertility and/or galactorrhea. Thus, the screening for macroprolactin is indicated not only for asymptomatic subjects but also for those without an obvious cause for their prolactin (PRL) elevation. Before submitting patients to macroprolactin screening and pituitary magnetic resonance imaging (MRI), one shoul...
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. However, atypical cases that lack monoclonal gammopathy and that present with hypothyroidism have been rep...
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
Heart Rhythm Society guidelines recommend obtaining thyroid function tests (TFTs) at amiodarone initiation and every six months thereafter in adults, with no specific pediatric recommendations. Untreated hypothyroidism in young children negatively affects brain development and somatic growth, yet the optimal screening frequency for pediatric patients remains unclear and limited data exists on pediatric amiodarone-induced thyroid dysfunction.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
ConclusionsWhen combined with ipilimumab, epacadostat ≤50 mg BID demonstrated clinical and pharmacologic activity and was generally well tolerated in patients with advanced melanoma.Trial registrationClinicalTrials.gov identifier,NCT01604889. Registration date, May 9, 2012, retrospectively registered.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
(Natural News) Hypothyroidism is a condition in which the thyroid gland does not produce enough thyroid hormones to keep the body functioning normally. Eating well-balanced meals is an important part of regulating a dysfunctional thyroid and the factors that contribute to the disease. Here are seven nutrients essential for hypothyroidism: Vitamin A: Vitamin A deficiency...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
CONCLUSIONS: This study of a patient with combined pituitary hormone deficiency revealed an unusual synonymous mutation of the HESX1 gene leading to abnormal RNA processing and underlines the importance of investigating silent variants that at first glance appear to be benign. PMID: 30888394 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Background: HIV-infected transwomen face multiple specific issues. Economic and social marginalization, sex work, substance abuse, hormonal consumption and silicone injection may affect the course of HIV infection and lead to metabolic and endocrine complications. Methods: A matched case–control study was performed between 2013 and 2015 in a University Hospital and compared metabolic syndrome (MetS), thyroid and adrenal functions in HIV-infected transwomen (i.e. cases) and cisgender HIV-infected men (i.e. controls) matched for age and antiretroviral therapy. The interaction between hormonal consumption, the cour...
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
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