Preoperative Selection and Optimization for Liver Resection in Colorectal Cancer Liver Metastases

AbstractPurpose of ReviewColorectal cancer is the third most common cancer in incidence and the leading cause of death among males and females. Colorectal cancer liver metastatic disease (CRCLM) is the most common cause of death in these patients. Liver resection is the best treatment modality to be offered for CRCLM patients; however, most patients are not good candidates for liver resection. The scope of this review is to discuss the preoperative selection process and the optimization methods that can be used to maximize the eligibility for liver resection in CRCLM.Recent FindingsThe advancement in perioperative management and the engagement of the multidisciplinary methodology in treating patients with colorectal liver metastasis resulted in improving the survival rates, decreasing perioperative complications, and expanding the criteria for liver resection for CRCLM patients.SummaryThe management of colorectal cancer liver metastasis is evolving. Patient selection and perioperative optimization play an essential role to offer a safer liver resection with a reasonable oncologic outcome; personalization of therapy is the next evolution in treating CRCLM patients.
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 18 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Juan Liao, Siyu Peng, Mei Long, Yaya Zhang, Huaming Yang, Yi Zhang, Jing HuangAbstractNatural halloysite clay nanotubes (halloysite nanotubes, HNTs) are potentially used in colon cancer therapy owing to their excellent physicochemical properties. However, the size-dependent interaction between HNTs and colon cancer cells is still an unresolved challenge. Herein, we analyzed the interfacial interactions between HNTs and colon cancer cells, and evaluated the size-dependent biological effects o...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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Source: Health Policy and Technology - Category: Health Management Source Type: research
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Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Condition:   Colorectal Cancer Metastatic Intervention:   Drug: Oxaliplatin Sponsors:   Criterium, Inc.;   Amgen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: PET Clin Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
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Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Abstract Cloning the open reading frame (ORF) of a protein-coding chimeric RNA into a mammalian expression vector is a simple, practiced way to study the function of the chimeric RNA. Here, we provide procedures for the insertion of the RRM2-C2orf48 fusion ORF into a mammalian expression vector, achieving the overexpression of the RRM2-C2orf48 fusion protein in a colon cancer cell line by retroviral transduction. PMID: 31728969 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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