Nitro-fatty acid formation and metabolism

Publication date: Available online 10 July 2018Source: Nitric OxideAuthor(s): Gregory R. Buchan, Gustavo Bonacci, Marco Fazzari, Sonia Salvatore, Stacy Gelhaus WendellAbstractNitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a great deal about their signaling, endogenous NO2-FA formation and metabolism is relatively unexplored. This review will cover what is currently known regarding proposed mechanisms of formation, dietary modulation of endogenous NO2-FA levels, and pathways of metabolism and detection of NO2FA and corresponding metabolites.

Source: Nitric Oxide - July 11, 2018 Category: Chemistry Source Type: research