Accelerated osteointegration of the titanium-implant coated with biocomponents, collagen/hydroxyapatite/bone morphogenetic protein-2, for bone-anchored hearing aid

Publication date: 25 July 2018Source: Journal of Industrial and Engineering Chemistry, Volume 63Author(s): Chul Ho Jang, Hyeongjin Lee, Minseong Kim, Geun Hyung KimAbstractA non-skin-penetrating bone-anchored hearing aid (BAHA-attract) with a single-point fixation system was recently developed for single-side deafness or sensorineural hearing loss. Here, we coated hydroxyapatitite (HA)/bone morphogenetic protein-2 (BMP-2)/collagen on the implant screw. To evaluate the osteogenesis induced by the modified titanium implant, we conducted in vitro and in vivo tests. The implant showed increased cell-proliferation of 2.3-fold greater than the control, and ALP activity/calcium mineralization results indicated enhanced osteogenic differentiation. According to oxytetracycline and alizarin expression results, the best enhanced peri-implant bone formation (87 ± 5.2%) was observed in the implant compared to the other groups.Graphical abstract
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research