Novel Approaches to Causality Adjudication in Drug-Induced Liver Disease

AbstractPurpose of ReviewDrug-induced liver injury (DILI) is a complex diagnosis dominantly based of exclusion.Recent FindingsCurrently available causality assessment instruments are considered to be suboptimal. Expert opinion appears to be best method to adjudicate causality, but is impractical to implement on a wide scale basis. Thus, new approaches are needed, for example, improving the specificity of current scoring systems. A further option would be to develop a system that utilizes computer-based scoring —which would reduce human error. Additionally, it would be ideal to have available drug-specific scoring systems, based on drugs’ characteristic “phenotypes” (presentation and pattern of injury). Eventually, a validated system could be integrated within electronic health information systems.SummaryThis review highlights an avenue to an improved causality assessment tool.
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research