Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage

This study indicates that α2(I) homotrimers are susceptible to MMP-1, proves that the presence of an α1(I) chain is not a requirement for α2(I) cleavage, and supports the importance of local unfolding of α2(I) in collagenase cleavage.
Source: Journal of Structural Biology - Category: Biology Source Type: research