Ulipristal acetate for the management of large uterine fibroids associated with heavy bleeding: a review

Publication date: Available online 21 April 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Guillaume E. Courtoy, Olivier Donnez, Marie-Madeleine DolmansAbstractUlipristal acetate (UPA), a selective progesterone receptor modulator (SPRM), offers new therapeutic options for the clinical management of large uterine fibroids associated with heavy menstrual bleeding or with other moderate or severe symptoms (bulk symptoms, pelvic pain, decreased quality of life). SPRM are synthetic compounds that exert an agonist or antagonist effect on target tissues by their binding to progesterone receptors. UPA reduces fibroid size, controls bleeding in a high percentage of women and significantly improves quality of life. The present review aims to provide insights into UPA indications and its mechanism of action.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research