Laterality in Parkinson's disease may predict motor and visual imagery abilities.

Laterality in Parkinson's disease may predict motor and visual imagery abilities. Funct Neurol. 2018 Apr/Jun;33(2):106-111 Authors: Lo Monaco MR, Laudisio A, Fusco D, Vetrano DL, Ricciardi D, Delle Donne V, Proietti F, Zuccalà G, Silveri MC Abstract Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Disparities in sidedness of motor disturbances are a distinctive feature of PD, and recent findings indicate that such disparities may similarly characterize cognition. Specifically, the deficits observed may depend upon which hemisphere is principally involved. Essentially, MI and VI are cognitive tasks subject to differential impairment and reflecting the prevalence of hemispheric impairment in PD. Motor imagery (assessed by the Vividness of Motor Imagery Questionnaire [VMIQ]) and VI (assessed by the Vividness of Visual Imagery Questionnaire [VVIQ] and Test of Visual Imagery Control [TVIC]) were examined in patients with asymmetric PD and in healthy elderly control subjects (HC group). VMIQ scores were similar in PD laterality subs...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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Visual hallucinations (VHs) are common in patients with Parkinson disease (PD), especially those with dementia, whereas auditory hallucinations are quite rare. Recent studies have revealed the involvement of several regions along the visual information-pro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
This study aimed to investigate the safety and efficacy of MRgFUS for PD by systematically reviewing related literature. PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the efficacy or sa fety of MRgFUS for PD and (2) published in English. Exclusion criteria were (1) nonhuman study, (2) review or meta-analysis or other literature types without original data, and (3) conference abstract without full text. Data on study characteristics, treatment parameters, efficacy, and adverse event s were collected. Descriptive synthesis of data was performed. Eleven studies containing 80...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Visual hallucinations (VH) are commonly found in the course of synucleinopathies like Parkinson's disease and dementia with Lewy bodies. The incidence of VH in these conditions is so high that the absence of VH in the course of the disease should raise questions about the diagnosis. VH may take the form of early and simple phenomena or appear with late and complex presentations that include hallucinatory production and delusions. VH are an unmet treatment need. The review analyzes the past and recent hypotheses that are related to the underlying mechanisms of VH and then discusses their pharmacological modulation. Recent m...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 7 December 2019Source: The Lancet NeurologyAuthor(s): Angelo Antonini
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
Authors: Fernandes B, Barbieri FA, Arthuso FZ, Silva FA, Moretto GF, Imaizumi LFI, Ngomane AY, Guimarães GV, Ciolac EG Abstract PURPOSE: To investigate the effect of high-intensity interval training (HIIT) versus moderate-intensity continuous exercise training (MICE) on hemodynamic and functional variables in individuals with Parkinson's disease. METHODS: Twenty participants (13 men) were randomly assigned to a thrice-weekly HIIT (n = 12) or MICE (n = 8) for 12 weeks. Hemodynamic (resting heart rate and blood pressure, carotid femoral pulse wave velocity, endothelial reactivity, and heart rate variabilit...
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
DiscussionThese findings provide evidence supporting the use of technology-driven interventions aiming at alleviating rhythm-related motor deficits in PD such as hypokinetic dysarthria or gait impairment in complement to more traditional therapeutic approaches.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
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