Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
Publication date: October 2017Source: Best Practice &Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Eivind Ness-Jensen, Jesper LagergrenAbstractGastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, strictures, Barrett's oesophagus and oesophageal adenocarcinoma. In addition to hereditary influence, GORD is associated with lifestyle factors, mainly obesity. Tobacco smoking is regarded as an aetiological factor of GORD, while alcohol consumption is considered a triggering factor of reflux episodes and not a causal factor. Yet, both tobacco smoking and alcohol consumption can reduce the lower oesophageal sphincter pressure, facilitating reflux. In addition, tobacco smoking reduces the production of saliva rich in bicarbonate, which is important for buffering and clearance of acid in the oesophagus. Alcohol also has a direct noxious effect on the oesophageal mucosa, which predisposes to acidic injury. Tobacco smoking cessation reduces the risk of GORD symptoms and avoidance of alcohol is encouraged in individuals where alcohol consumption triggers reflux.
Authors: Hwang S, Ren T, Gao B Abstract Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy drinking on steatohepatitis and discuss the underlying mechanisms obtained from the study of several mouse models. High-fat diet (HFD) feeding and binge ethanol synergistically induced steatohepatitis and fibrosis in mice with significant intrahepatic neutrophil infiltration; such HFD-plus-ethanol treatment markedly up-regulat...
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
Publication date: Available online 18 September 2020Source: Obesity Research &Clinical PracticeAuthor(s): Giancarlo Condello, Chih-Yen Chen
Publication date: Available online 18 September 2020Source: Obesity Research &Clinical PracticeAuthor(s): April Prunty, M. Kathleen Clark, Amy Hahn, Stephanie Edmonds, Amy O’Shea
Abstract Coronavirus disease 2019 (COVID-19) is a global public health concern that can be classified as mild, moderate, severe, or critical, based on disease severity. Since the identification of critical patients is crucial for developing effective management strategies, we evaluated clinical characteristics, laboratory data, treatment provided, and oxygenation to identify potential predictors of mortality among critical COVID-19 pneumonia patients. We retrospectively utilized data from seven critical patients who were admitted to our hospital during April 2020 and required mechanical ventilation. The primary en...
Hospitals and emergency services should be prepared for a possible influx of adolescents and young adults with alcohol-related emergencies as their localities open up after COVID-19 lockdowns, suggests astudy in the Journal of Adolescent Health. The study found that the proportion of alcohol-related emergency department (ED) visits to two Italian hospitals jumped for this population in the weeks following the end of this spring ’s lockdown compared with the same time frame in 2019.Veronica Grigoletto, M.D., of the University of Trieste and colleagues analyzed data on ED visits of patients aged 13 to 24 years that occ...
Publication date: Available online 17 September 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Mohammed S. Razzaque, Azeddine Atfi
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC05387B, CommunicationSilvia Rodr íguez-Nuévalos, Ana M. Costero, Pau Arroyo, José A. Sáez, Margarita Parra, Félix Sancenón, Ramón Martínez-Máñez Chemosensors for naked-eye detection of the submission drug GHB in beverages. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Conclusion: There was no significant improvement in the patient GERD symptoms increasing the dose of oral esomeprazole during the 6 months of study. N-of-1 trials in chronic pathologies including GERD are recommended due to their potential value as systematic methods that evaluate therapies without strong scientific evidence. PMID: 31929980 [PubMed - in process]