Effect of Biochanin a on Retina Level of VEGF, TNF-a and IL-1B in STZ Induced Diabetic Rats

Publication date: Available online 3 April 2018Source: Canadian Journal of DiabetesAuthor(s): Maryam Eskandari Mehrabadi, Zahra Salemi, Saeid Babaie, Mitra PanahiAbstractObjectivesWithout proper medication for the treatment of diabetic retinopathy (DR), retinal cells become malnourished and degenerate, which results to damage in vision cells and can lead to blindness. Flavonoids such as biochanin A (BCA) can directly target different facets of angiogenesis. We assessed the effect of administrating BCA on angiogenic and inflammatory markers in the retina of diabetic rats.MethodsWe selected randomly 2 groups from thirty male wistar rats. We used six rats in each group. We selected one control group or group1 (receiving 0.5% DMSO) and the second one or group 2 by receiving 10 mg/kg body weight (bw) of BCA. Type1 diabetes was induced in other rats by a single injection of streptozotocin (STZ) (55 mg/kg bw). Diabetic rats randomly divided into 3 groups as followings: group 3 or diabetic control group (receiving 0.5% DMSO), groups 4 and 5 were receiving 10 and 15 mg/kg bw of BCA respectively. The concentration of VEGF, TNFα and IL-1β were quantified in the retina of diabetic rats that received BCA for 6 weeks, and were compared to control rats.ResultsAdministration of BCA to diabetic rats resulted in a significant restoration of fasting blood glucose (FBG). After Administration of BCA, retina concentrations of VEGF, TNF-α and IL-1β decreased in the two groups ...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Authors: Steinle JJ Abstract Despite decades of research, diabetic retinopathy remains the leading cause of blindness in working age adults. Treatments for early phases for the disease remain elusive. One pathway that appears to regulate neuronal, vascular, and inflammatory components of diabetic retinopathy is the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. In this review, we discuss the current literature on cAMP actions on the retina, with a focus on neurovascular changes commonly associated with preproliferative diabetic retinopathy models. PMID: 32476815 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
Basel, 27 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced positive topline results from the phase III Archway study, evaluating Port Delivery System with ranibizumab (PDS) in people living with neovascular or “wet” age-related macular degeneration (nAMD). PDS is a permanent refillable eye implant, approximately the size of a grain of rice, which continuously delivers a customised formulation of ranibizumab over a period of months. The Archway trial met its primary endpoint, demonstrating that patient s with PDS who received refills every six months achieved visual acuity outcomes equivalent to tho...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Basel, 22 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) will present new pooled pivotal satralizumab safety results for the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare, debilitating central nervous system disorder. These data are being presented at the 6th Annual Meeting of the European Academy of Neurology (EAN) and show satralizumab was well-tolerated in a broad patient population – including adolescents, for whom there is no approved medicine. Satralizumab is an investigational humanised monoclonal antibody that targets the interleukin-6 (IL-6) receptor, believed to play a key role in the i...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Conclusions/interpretationOur data show no association between Lp(a) plasma levels and theLPA SNPs with known effect on Lp(a) plasma levels with the development of microvascular complications in type 2 diabetes. This indicates that Lp(a) does not play a major role in the development of microvascular complications. However, larger studies are needed to exclude minimal effects of Lp(a) on the development of microvascular complications.
Source: Diabetologia - Category: Endocrinology Source Type: research
A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Müller cells. Exp Eye Res. 2020 May 11;:108065 Authors: Du J, Wang Y, Tu Y, Guo Y, Sun X, Xu X, Liu X, Wang L, Qin X, Zhu M, Song E Abstract Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus that leads to blindness in the working-age population. Retinal Müller cells proliferate and produce pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF)...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
This study was conducted using optical coherence tomography angiography and noninvasive imaging modalities. Microaneurysms were evaluated for location, flow, and adjacent retinal tissue changes to establish knowledge of possible vision-threatening features. Methodology: This is a hospital-based, cross-sectional observational study. Eighteen patients with diabetic maculopathy were included in the study. Fundus photo, red-free filter image, infrared images with shadowgrams, optical coherence tomography cross sections, and optical coherence tomography angiography were analyzed. Mean, standard deviation, odds ratio, and 95% co...
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Diabetic retinopathy (DR) and diabetic macular edema (DME) are the leading causes of permanent blindness in the working-age population. Automatic grading of DR and DME helps ophthalmologists design tailored treatments to patients, thus is of vital importance in the clinical practice. However, prior works either grade DR or DME, and ignore the correlation between DR and its complication, i.e., DME. Moreover, the location information, e.g., macula and soft hard exhaust annotations, are widely used as a prior for grading. Such annotations are costly to obtain, hence it is desirable to develop automatic grading methods with on...
Source: IEE Transactions on Medical Imaging - Category: Biomedical Engineering Source Type: research
In conclusion, circ_0002570 might serve as a potential target for diagnosis and treatment for DR. PMID: 32319024 [PubMed - as supplied by publisher]
Source: Cell Stress and Chaperones - Category: Cytology Authors: Tags: Cell Stress Chaperones Source Type: research
Conclusion: There is no systematic DR screening program, and HR and infrastructure distribution was not aligned to the population need in the western province. Urgent attention should be paid to expand the service delivery and mid-level HR training for DR screening and treatment in this region.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
CONCLUSIONS Multiple bioinformatics analyses verified that FH could be used as a potential diagnostic marker and new therapeutic target of DR. PMID: 32294661 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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