The diagnostic accuracy of increased late night salivary cortisol for Cushing ’s syndrome: a real-life prospective study

ConclusionsLNSC measured in automated chemiluminescence is reliable in clinical practice: it present a high diagnostic accuracy to exclude hypercortisolism in patients with normal cortisol levels. MS could be used to reduce the number of false-positive results; nevertheless, some non-CS subjects with functional hypercortisolism could have a mild impairment of cortisol rhythm.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research