GSE116686 Diurnal oscillations in human salivary microRNA and microbial transcription

Contributor : Frank A MiddletonSeries Type : Other ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe investigated daily oscillations in salivary miRNA and microbial RNA to explore relationships between these components of the gut-brain-axis and their implications in human health. Nine subjects provided 120 saliva samples at designated times, on repeated days. Samples were divided into three sets for exploration and cross-validation. Identification and quantification of host miRNA and microbial RNA was performed using next generation sequencing. Eleven miRNAs and 11 microbial RNAs demonstrated consistent diurnal oscillation across the first 2 sample sets and accurately predicted collection time in the hold-out set based on multivariate logistic regression modeling. Associations among five circadian miRNAs and four circadian microbial RNAs were observed.

Source: GEO: Gene Expression Omnibus - July 6, 2018 Category: Genetics & Stem Cells Tags: Other Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research