HO-1 regulates the function of Treg: Association with the immune intolerance in vitiligo.

In this study, we explored the molecular and cellular alterations accounting for the impaired Treg response in vitiligo. Our results showed that the amount of Tregs was drastically reduced in peripheral blood of active vitiligo patients. Furthermore, the immunoregulatory function of Tregs was attenuated, with lower expression of CTLA4, IL-10 and TGF-β. Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were correspondingly decreased in serum of vitiligo patients. In addition, we treated the Tregs from vitiligo patients with Hemin, an agonist of HO-1, and found that enhanced HO-1 expression restored the function of Tregs by up-regulating IL-10 expression. Our study demonstrates the essential role of HO-1 in the impaired Treg response in vitiligo and indicates the potential of HO-1 as a therapeutic target in vitiligo management.
PMID: 29974998 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - July 5, 2018 Category: Molecular Biology Authors: Zhang Q, Cui T, Chang Y, Zhang W, Li S, He Y, Li B, Liu L, Wang G, Gao T, Li C, Jian Z Tags: J Cell Mol Med Source Type: research