Safety and pharmacokinetics of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler (BGF MDI) in healthy adult subjects of Japanese descent
DiscussionBoth doses of BGF MDI were well tolerated in healthy subjects of Japanese descent and the systemic exposure to budesonide was dose proportional for BGF MDI 160/14.4/10 μg and BGF MDI 320/14.4/10 μg. The safety and pharmacokinetics for BGF MDI 160/14.4/10 μg and BGF MDI 320/14.4/10 μg in Japanese subjects were comparable to data from previous studies in Western populations, which suggests that the safety and efficacy profile of BGF MDI should be similar in Western and Japanese subjects.
Conclusion: Patients with increasing severity of COPD had a significantly greater serum inflammatory marker level and poorer nutritional status.
Conclusions: Comprehensive troubles in living with COPD paradoxically prevents patients' prospect of overcoming a perceived lack of trust in their body during standard pulmonary rehabilitation. Enhancing breath management has a significant impact on COPD patients' trust in own capabilities to improve well-being and health. Future rehabilitation must accommodate COPD patients' troubles by longer-lasting, well-coordinated, individually supportive and more easily accessible programmes. PMID: 31432771 [PubMed - in process]
Conclusions: Finally, implications of this broader perspective for interventions to improve outcomes in aging adults with multimorbidity are briefly considered. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
In conclusion the burden of extra respiratory symptoms in patients with hospitalized for a COPD exacerbation is significant and impact significantly on health/functional status.This article is protected by copyright. All rights reserved.
Conclusion: In this study, the coastal areas of South Korea carry a higher burden than the national population. Additionally, chronic diseases compose the majority of the health burden in coastal areas. Despite the limitation of data, YLD was the best tool available for evaluating the health outcomes in specific areas, and has the advantage of simplicity and timely analysis.
ZusammenfassungIm Jahr 2018 wurde der Schwellenwert des mittleren pulmonalarteriellen Drucks f ür die Definition des Vorliegens einer pulmonalen Hypertonie (PH) geändert; demnach liegt die Prävalenz der PH nun bei etwa 1 % der globalen Bevölkerung. Eine wichtige Rolle bei der Entstehung von Arrhythmien bei PH-Patienten spielen die erhöhte Aktivität des sympathischen Nervensystems, ele ktrisches Remodeling und in dessen Folge eine relative Ischämie des rechten Vorhofs. Supraventrikuläre Arrhythmien wurden in einigen Studien hinsichtlich ihres Einflusses auf den Verlauf bei PH-Patien...
AbstractIntroductionPatients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) ‐overlap syndrome‐ have a substantially greater risk of morbidity and mortality, compared to those with either COPD or OSA alone.ObjectivesThe aim of this retrospective study was to identify clinical modifiable factors associated with COPD exacerbations and all ‐cause mortality in patients with overlap syndrome.MethodsThe electronic records of patients with simultaneous COPD and OSA who had a documented acute exacerbation of COPD during a 42 ‐month period were evaluated for reviewed. A control group of o...
Single inhaler triple therapies providing an inhaled corticosteroid, a long-acting muscarinic antagonist, and a long-acting β2-agonist (ICS/LAMA/LABAs) are an emerging treatment option for chronic obstructive pulmonary disease (COPD). Nevertheless, questions remain regarding the optimal patient population for triple therapy as well as the benefit:risk ratio of ICS treatment.
Authors: Sehgal IS, Agarwal R, Dhooria S, Prasad KT, Kalpakam H, Aggarwal AN PMID: 31424281 [PubMed - as supplied by publisher]
Authors: Gianella GE, Miranda JJ, Hurst JR Abstract The diagnosis of chronic obstructive pulmonary disease (COPD), a global health problem, is challenging in resource-constrained settings. Spirometry with an obstructive pattern after the administration of bronchodilators is required for the diagnosis of COPD. Existing COPD treatment guidelines, largely derived from studies performed in populations of cigarette-smokers, recommend pharmacologic interventions with a tendency to include new-and expensive-drugs as first line agents. As the different factors that cause nonsmokers to develop COPD lead to different phenoty...