Peyer's patches-derived CD11b+ B cells recruit regulatory T cells through CXCL9 in DSS-induced colitis.

This study, based on the dextran sulfate sodium (DSS)-induced colitis model, revealed that Tregs are significantly increased in PPs, along with CD11b+ B cell induction. Immunofluorescence staining showed that infiltrated Tregs were located around CD11b+ B cells and produced TGF-β, thereby inducing IgA+ B cells. Furthermore, in vivo and in vitro studies revealed that CD11b+ B cells in PPs had the capacity to recruit Tregs into PPs rather than promoting their proliferation. Finally, we found that Treg recruitment was mediated by the chemokine CXCL9 derived from CD11b+ B cells in PPs. These findings demonstrate that CD11b+ B cells induced in PPs during colitis actively recruit Tregs to accomplish IgA isotype switch in a CXCL9-dependent manner. This article is protected by copyright. All rights reserved.
PMID: 29969845 [PubMed - as supplied by publisher]

Source: Immunology - July 3, 2018 Category: Allergy & Immunology Authors: Wang Z, Zhang H, Liu R, Qian T, Liu J, Huang E, Lu Z, Zhao C, Wang L, Chu Y Tags: Immunology Source Type: research