A systematic review of network meta-analyses among patients with Nonvalvular atrial fibrillation: A comparison of efficacy and safety following treatment with direct oral anticoagulants

Direct oral anticoagulants (DOACs) are indicated for the prevention of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation. While no head-to-head randomized controlled trials (RCTs) exist that evaluate the efficacy and safety of DOACs, network meta-analyses (NMAs) based mainly on RCTs for each DOAC, and using varying methodologies, have been published. This systematic literature review summarizes the evidence on stroke/SE bleeding events, mortality, and other adverse events from NMAs that reported indirect comparisons of DOACs.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research