Supplemental antioxidants may reduce exacerbations in cystic fibrosis

(American Thoracic Society) An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Contributors : Tara Gallagher ; Katrine WhitesonSeries Type : Expression profiling by high throughput sequencingOrganism : Stenotrophomonas maltophiliaWe sought to determine how a cystic fibrosis isolate of Stenotrophomonas maltophilia responds to relevant pH gradients (pH 5, 7, and 9) by growing the bacterium in phosphate buffered media and conducting RNAseq experiments. Our data suggests acidic conditions are stressful for strain FLR19, as it responded by increasing expression of stress-response and antibiotic-resistance genes.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Stenotrophomonas maltophilia Source Type: research
AbstractCystic fibrosis is the most common inherited condition in the Caucasian population and is associated with significantly reduced life expectancy. Recent advances in treatment have focussed on addressing the underlying cause of the condition, the defective production, expression and function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Several drugs with different modes of action have produced promising results in clinical trials, and some have been incorporated into routine clinical care for specific patients in many countries worldwide. Further trials continue to explore the safety and...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
CONCLUSION: Here, we summarize new patented peptides that have been developed in the last few years and advanced technologies for inhaled drug delivery to treat Cystic Fibrosis. PMID: 30318010 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Burkholderia cenocepacia is an opportunistic pathogen that infects cystic fibrosis patients, causing pneumonia and septicemia. B. cenocepacia has intrinsic antibiotic resistance against monobactams, aminoglycosides, chloramphenicol and fluoroquinolones that is contributed by a homologue of BpeB, which is a member of the resistance-nodulation-cell division (RND)-type multidrug-efflux transporters. Here, the cloning, overexpression, purification, construct design for crystallization and preliminary X-ray diffraction analysis of this BpeB homologue from B. cenocepacia are reported. Two truncation variants were designed to rem...
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: membrane transporter multidrug resistance drug exporter Burkholderia research communications Source Type: research
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF patients. Prolonged infections are accompanied by adaptation of P. aeruginosa to the unique conditions of the CF lung environment, as well as marked diversification of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Ultrasound in Obstetrics&Gynecology,Volume 52, Issue S1, Page 63-64, October 2018.
Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Conclusion: Although the underlying mechanisms are not well understood, results can be hypothesized that LBW (respectively prematurity) may lead to the secondary and often transitory hypothyroidism while cystic fibrosis and LCHADD may manifest already prenatally and result into preterm birth and LBW.What is Known:• The percentage of low birthweight (LBW) neonates in the Czech Republic has been increasing.•Previously published studies reported positive association between LBW and congenital hypothyroidism and cystic fibrosis.What is New:• The association between LCHADD and LBW has not yet been described.&bull...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
oup Abstract RATIONALE: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors is unclear. OBJECTIVES: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake (VO2peak) following rigorous adjustment for other predictors. MEASUREMENTS AND MAIN RESULTS: Data from 10 CF-centers in Australia, Europe and North America were collected retrospectively. 510 patients completed a cycle CPET between January 2000 and December 2007, of which 433 f...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
She has cystic fibrosis and shared a day in her life to show what it's like for her.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
This report provides an example of the signs, symptoms and sonographic findings associated with this rare fetal complication and explores the intricacies of prenatal genetic testing.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
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