Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability.

Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability. Curr Drug Metab. 2018 Jun 28;: Authors: Yao JF, Yang H, Zhao YZ, Xue M Abstract Peptides are used increasingly as therapeutics and biomarkers because of the development of peptide synthesis technologies. Although peptides are associated with a variety of advantages that include high pharmaceutical activity and low toxicity, the therapeutic use of peptides is limited because of their poor metabolic stability in vivo. The main cause of this instability is that peptides are readily degraded by peptidases distributed widely in the body. This review summarizes peptidases present in the gastrointestinal tract, blood, liver, kidney, nasal cavity and placental barrier, and provides an overview of the metabolic characteristics of peptides and recent strategies for improving the metabolic stability of peptide drugs. PMID: 29956618 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research