Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal fibroblasts

In this study, it was revealed that there are two chemotypes (Types A and B) in the root of the original plant,O. japonicus. Methylophiopogonanone A (compound1) and methylophiopogonanone B (compound2) were isolated as index compounds from Type A and compound1 and ophiopogonanone A (compound3) from Type B. In addition, ophiopogonin B (compound4) was isolated as the main steroidal saponin from both Type A and B. The results indicated that two different methanol extracts (from Types A and B) and the main constituents ofO. japonicus (compound1–4), significantly downregulated the expression of interleukin (IL)-6 and IL-8, which were enhanced by senescent normal human dermal fibroblasts. Moreover, the two different methanol extracts and compounds1–4 decreased IL-6 production in a strong and concentration-dependent manner by the ELISA method.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research