IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN

Conclusions IL-10R engagement optimizes Treg-mediated suppression of Th17 immunity. We hypothesize a feed-forward loop, in which IL-10Ra signaling reinforces IL-10 secretion by Tregs which potently controls Th17 development via direct and indirect mechanisms. IL-10R thus may be a promising therapeutic target for the treatment of GN.

Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Diefenhardt, P., Nosko, A., Kluger, M. A., Richter, J. V., Wegscheid, C., Kobayashi, Y., Tiegs, G., Huber, S., Flavell, R. A., Stahl, R. A. K., Steinmetz, O. M. Tags: Basic Research Source Type: research