Higher doses of rifampin appear more effective in fighting TB without increasing risk of adverse events

(American Thoracic Society) Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: Available online 17 January 2019Source: International Journal of PaleopathologyAuthor(s): Dorthe Dangvard Pedersen, George R. Milner, Hans Jørn Kolmos, Jesper Lier BoldsenAbstractSensitivity and specificity estimates for 18 skeletal lesions were generated from modern skeletons for future paleoepidemiological analyses of tuberculosis prevalence in archaeological samples. A case-control study was conducted using 480 skeletons from 20th century American skeletal collections. One-half of the skeletons were documented tuberculosis cases (Terry Collection). The remaining age and sex-matched skeletons wer...
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
ConclusionQuantiFERON-TB Gold assay is an effective tool in diagnosing tuberculosis infection in pediatric population. False positive reactions with tuberculin skin test are common as there is cross reactivity with NTM and BCG vaccination. Both the sensitivity and specificity were better than the tuberculin skin test. So it is better than tuberculin skin test and the diagnostic yield is better. However, this test shouldn’t be used as gold standard for diagnosis of tubercular disease in children.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Authors: Furin J Abstract INTRODUCTION: Pediatric tuberculosis (TB) is a significant global health threat and is one of the top ten causes of death in children. There are a number of diagnostic, treatment, and preventive innovations that have been developed in the last decade for TB, however, these are out of reach for many children in the world. Areas covered: A comprehensive review of the literature on TB in children was done using PubMed and Ovid databases from January 1, 1996 up to October 31, 2018. Topic areas covered included diagnosis of TB, treatment of TB (including novel medications and regimens), prevent...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
(CNN) — An international team of scientists has developed a diet it says can improve health while ensuring sustainable food production to reduce further damage to the planet. The “planetary health diet” is based on cutting red meat and sugar consumption in half and upping intake of fruits, vegetables and nuts. And it can prevent up to 11.6 million premature deaths without harming the planet, says the report published Wednesday in the medical journal The Lancet. The authors warn that a global change in diet and food production is needed as 3 billion people across the world are malnourished — which in...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Source Type: news
Haiko Schurz, Craig J. Kinnear, Chris Gignoux, Genevieve Wojcik, Paul D. van Helden, Gerard Tromp, Brenna Henn, Eileen G. Hoal, Marlo M öller
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
[Ghanaian Times] Gains made in the fight against tuberculosis (TB) could be eroded, if they were not sustained, Professor Abraham Kwabena Anang, Director of the Noguchi Memorial Institute for Medical Research (NMIMR), has said.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
PMID: 30653488 [PubMed - in process]
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Tuberculosis patients often experience hospitalization. Inpatient services may result in high medical expenditures. It is important to explore the hospitalization rates of tuberculosis patients and the potenti...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
ConclusionsIn China, active case finding (ACF) could be implemented among elderly people aged 65 and above with underweight, diabetes, close contact history and previous TB history as a priority, which will get significant yields and be cost-effective.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
ocart The biology of the group of plant hormones termed cytokinins is reviewed to reveal areas where further studies of cytokinin-binding proteins could be significant. Such areas include: inhibition of human tumour cell growth by cytokinin ribosides, the role of cytokinins in the development of diverse micro-organisms including the cyanobacteria and Mycobacterium tuberculosis, the very rapid responses of plant cells to exogenous cytokinins, and other aspects of cytokinin plant biology. Photoaffinity labelling (PAL) coupled to the recent advances in HPLC of proteins and mass spectral analysis and sequencing of proteins...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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