Higher doses of rifampin appear more effective in fighting TB without increasing risk of adverse events

(American Thoracic Society) Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
This study was performed to demonstrate the clinical and histological features of GR and LMDF and to establish their relationship to tuberculous etiology by molecular technique. All the cases of GR (n = 20) and LMDF (n = 10) diagnosed on skin biopsy over the past 6 years were reviewed along with their clinical detail. Polymerase chain reaction (PCR) was performed using primers specific for Mycobacterium tuberculosis. The mean age of patients with GR was 45 years 10 months (range 18–75 years) as compared to 33 years 5 months (range 18–57 years) in patients with LMDF. The GR cases comprised 13 men and 7 women pat...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
Conclusion Rifampicin is the leading cause of AKI. Levofloxacin may be an alternative to rifampicin thanks to its safety and potency. Restarting anti-TB treatment without rifampicin and short-term steroid administration may be a feasible management for AKI. PMID: 30333388 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractBackgroundTuberculosis (TB) is still one of the most serious infectious diseases in the mainland of China. So it was urgent for the formulation of more effective measures to prevent and control it.MethodsThe data of reported TB cases in 340 prefectures from the mainland of China were extracted from the China Information System for Disease Control and Prevention (CISDCP) during January 2005 to December 2015. The Kulldorff ’s retrospective space-time scan statistics was used to identify the temporal, spatial and spatio-temporal clusters of reported TB in the mainland of China by using the discrete Poisson proba...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Be aware of the burden of tuberculosis among high-risk population is important. Three hundred fifty-two children were participated in this study. Survival analysis was conducted. We assessed the incidence of t...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
Condition:   Tuberculosis, Pulmonary Intervention:   Diagnostic Test: Truenat MTB Sponsors:   Foundation for Innovative New Diagnostics, Switzerland;   Burnet Institute;   National Institute for Research in Tuberculosis, Chennai, India;   Universidad Peruana Cayetano Heredia;   Ethiopian Public Health Institute;   PD Hinduja Hospital and Medical Research Centre, Mumbai, India Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article discusses the risk of exposure and infection with tuberculosis and the protection provided by childhood vaccination.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusion: Lung carcinoma is presently the leading cause of cancer deaths while TB is still a common cause of death in developing countries. Cytopathology has a definite role in diagnosis of malignant lesions and also contributes in diagnosis of unsuspected chronic infections. Cytological diagnosis is fairly accurate if the specimen obtained is adequate and representative.
Source: Journal of Cytology - Category: Cytology Authors: Source Type: research
ConclusionsAntigen detection tests are promising tools to improve detection of and ultimately reduce the burden of histoplasmosis mortality in patients with advanced HIV disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This article aims to assess the odds of the burden of TB in urban slums through a systematic review and meta-analysis. Four electronic datab ases were searched for studies published between 1993 and 2017, with TB defined as at least one sputum smear-positive. The review followed the PRISMA protocol and information was extracted from articles for a full-text review to determine eligibility. Odds ratios were calculated for studies reportin g sputum smear-positive TB cases in slum settings with national incidence as a comparison. Summary estimates were calculated using the random effects model (95% CI) and publication bias wa...
Source: Journal of Urban Health - Category: Health Management Source Type: research
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