An Exploratory Study of Exercise-related Effects on Memory and Hippocampal Connectivity in Schizophrenia.

An Exploratory Study of Exercise-related Effects on Memory and Hippocampal Connectivity in Schizophrenia. Clin Schizophr Relat Psychoses. 2018 Jun 26;: Authors: Schwartz B, Teslovich T, You X, Cho J, Schooler N, Kokkinos P, Vaidya C Abstract Memory impairment in schizophrenia has been linked to abnormal functioning of fronto-temporal networks. In this pilot study, we investigated whether 12-weeks of exercise improved hippocampal-dependent memory functions and resting-state functional connectivity in middle-aged adults with schizophrenia. The exercise regimen was feasible, well-attended, and safe. There was a pre- to post-intervention increase in spatial memory accuracy that was correlated to an increase in hippocampal-prefrontal cortex connectivity. No increase was found in pattern separation performance or hippocampal volume. A controlled trial is needed to replicate these findings and elucidate the functional brain networks underlying exercise-induced cognitive improvement in schizophrenia. PMID: 29944414 [PubMed - as supplied by publisher]
Source: Clinical Schizophrenia and Related Psychoses - Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research