Contribution of the Y Chromosome to Stallion Fertility

While it is well established that mammalian male fertility has a genetic component, genomics tools for evaluating fertility in stallions are limited. The Y chromosome is enriched with genes important for spermatogenesis and sperm functions as evidenced by human and mouse studies showing causative links between Y chromosome rearrangements, mutations, copy number variants (CNVs) and various male infertility phenotypes; hence, Y chromosome studies were initiated in the horse. We recently produced a 9.5 Mb annotated reference sequence for the male specific region of the horse Y (MSY).

Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: C. Castaneda, A. Hillhouse, J. Janecka, R. Juras, A. Ruiz, A. Tibary, C.C. Love, D.D. Varner, T. Raudsepp Source Type: research