Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function...

Source: Molecular Neurodegeneration - June 22, 2018 Category: Neurology Authors: Andrew E. Arrant, Alexandra M. Nicholson, Xiaolai Zhou, Rosa Rademakers and Erik D. Roberson Tags: Research article Source Type: research