Midwife reveals how her hands and feet wouldn ’t stop growing – because of a brain tumour
Chloe Powell, a 26-year-old midwife from Bristol, developed acromegaly because of a benign brain tumour, which made her hands and feet grow uncontrollably, and her facial features swell up.
The objectives of the proposed method are 1) removing baseline in frequency domain using SSA; 2) extracting the underlying components of MRS signal based on the suggested novel covariance matrix; and 3) reconstructing metabolite of interest by combining some of the extracted components using a novel cost function. Performance of the proposed method is evaluated using both synthetic and real MRS signals. The obtained results show the effectiveness of the proposed technique to accurately remove baseline and extract metabolites of MRS signal.
AbstractFEZ family zinc finger 1 (FEZF1) is an essential transcription factor during olfactory development. In gastrointestinal tumors, FEZF1 plays an oncogenic role through DNA demethylation. However, the role of FEZF1 in the prognosis of human glioma prognosis remains unclear. In this research, we discovered that FEZF1 was significantly increased in glioma tissues in contrast to normal brain tissues (NBTs;P
Publication date: September 2018Source: Biomedical Signal Processing and Control, Volume 46Author(s): Supriya Patil, Gourish Naik, Radhakrishna Pai, Rajendra GadAbstractInvention of the microarray technology has rendered it possible to inspect the whole genome at once in cancer classification. However, in order to curtail the computational complexity and augment the accuracy of cancer classification, it is essential to sift the vast microarray data for the informative genes. In this paper, Thresholding and Ratio methods are presented, individually as well as conjointly (hybrid method) to choose optimal gene subset from the...
In conclusion, the present study demonstrated that FOXK1 promoted cell growth through activating wnt/β-catenin pathway and is negatively regulated by miR-137 in glioma. PMID: 30018719 [PubMed]
Authors: Wang D, Yang S, Wang H, Wang J, Zhang Q, Zhou S, He Y, Zhang H, Deng F, Xu H, Zhong S, Fu L, Tang J Abstract Circular RNAs (circRNAs), a novel type of non-coding RNAs, presented as covalently closed continuous loops. Recent researches had found that circRNAs could function as microRNA sponges, regulators of gene transcription and encoding proteins. They were relatively stable and expressed widely in cytoplasm, which played important roles in carcinogenesis of cancers, such as esophageal cancer, gastric cancer, colorectal cancer, hepatocarcinoma, bladder cancer, glioma, breast cancer, osteosarcoma and so on...
Condition: Pediatric Brain Tumor Interventions: Procedure: Ketogenic diet; Drug: BCNU Sponsor: Washington University School of Medicine Not yet recruiting
Publication date: April–June 2018Source: Journal of Ayurveda and Integrative Medicine, Volume 9, Issue 2, Supplement 1Author(s): Serene Xavier, K.R. Sundaram, Dilip Panikar, Shantikumar Nair, Krishnakumar Menon, Lakshmi Sumitra Vijayachandran
Cancers, Vol. 9, Pages 103: Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review Cancers doi: 10.3390/cancers9080103 Authors: Ryuya Yamanaka Eisuke Abe Toshiteru Sato Azusa Hayano Yasuo Takashima Pituitary adenomas are often treated with radiotherapy for the management of tumor progression or recurrence. Despite the improvement in cure rates, patients treated by radiotherapy are at risk of development of secondary malignancies. We conducted a comprehensive literature review of the secondary intracranial tumors that occurred following radiotherapy to pituitary aden...
Conclusion Although the use of radiotherapy in patients with acromegaly has decreased with advances in medical treatments, it remains an effective treatment option after unsuccessful surgery and/or resistance or unavailability of medical therapy. Long-term studies evaluating secondary morbidity and mortality rate after the new stereotactic techniques are needed, in order to evaluate their potential brain-sparing effect.
Conclusion Our data show that intraoperative ICG VA can be a useful and easily applicable additional diagnostic tool for visualization of pituitary lesions using the microscopic approach.