Midwife reveals how her hands and feet wouldn ’t stop growing – because of a brain tumour

Chloe Powell, a 26-year-old midwife from Bristol, developed acromegaly because of a benign brain tumour, which made her hands and feet grow uncontrollably, and her facial features swell up.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 22 February 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): P. Sriramakrishnan, T. Kalaiselvi, R. RajeswaranAbstractThe proposed work develops a rapid and automatic method for brain tumour detection and segmentation using multi-sequence magnetic resonance imaging (MRI) datasets available from BraTS. The proposed method consists of three phases: tumourous slice detection, tumour extraction and tumour substructures segmentation. In phase 1, feature blocks and SVM classifier are used to classify the MRI slices into normal or tumourous. Phase 2 contains fuzzy c means (FCM) alg...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
Source: Endocrine - Category: Endocrinology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Bing Wu, Heyuan Wang, Lenign Zhang, Chenglin Sun, Hang Li, Chunyan Jiang, Xiaodong LiuAbstractAs a key regulator of DNA translesion synthesis (TLS) pathway, RAD18 is reported to be abnormally expressed in many kinds of cancers. In glioma, RAD18 was overexpressed in the primary and recurrent glioblastoma multiforme specimens, and its overexpression weakened ionizing radiation-induced apoptosis in glioma A172 cells. Moreover, A172 cells with mutational P53 also showed enhanced radiation resistance. And RAD18 activation induced by cycli...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2019Source: Biomedicine &Pharmacotherapy, Volume 112Author(s): Jaturon Kwanthongdee, Chotchanit Sunrat, Bamroong Munyoo, Patoomratana Tuchinda, Napason Chabang, Witchuda SaengsawangAbstractGlioblastoma is the most common and the most malignant form of brain tumor. This devastating tumor results in death within a year after diagnosis. Although the tumor mass can be surgically removed, glioma cells invade other areas in the brain leading to tumor recurrence and poor prognosis. Therefore, new agents that can overcome cancer cell invasion are urgently required. Phyllanthus taxodiifolius Beille (P. t...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Abstract A mitochondria-targeted ratiometric fluorescent probe based on the fluorophore pyrido[1,2-a]benzimidazole was developed. It showed high sensitivity and selectivity toward SO2 derivatives in water. The probe was also successfully applied to detect intrinsically generated SO2 derivatives in living glioma cells, which may be helpful in ascertaining the biological roles of SO2 in mitochondria. PMID: 30782364 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
ConclusionManual tumor segmentations on MRI have reasonable agreement for use in spatial and volumetric analysis. Agreement in spatial overlap is of concern with segmentation after surgery for glioblastoma and with segmentation of non-glioblastoma by non-experts.Graphical abstract
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Cancers, Vol. 9, Pages 103: Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review Cancers doi: 10.3390/cancers9080103 Authors: Ryuya Yamanaka Eisuke Abe Toshiteru Sato Azusa Hayano Yasuo Takashima Pituitary adenomas are often treated with radiotherapy for the management of tumor progression or recurrence. Despite the improvement in cure rates, patients treated by radiotherapy are at risk of development of secondary malignancies. We conducted a comprehensive literature review of the secondary intracranial tumors that occurred following radiotherapy to pituitary aden...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion Although the use of radiotherapy in patients with acromegaly has decreased with advances in medical treatments, it remains an effective treatment option after unsuccessful surgery and/or resistance or unavailability of medical therapy. Long-term studies evaluating secondary morbidity and mortality rate after the new stereotactic techniques are needed, in order to evaluate their potential brain-sparing effect.
Source: Pituitary - Category: Endocrinology Source Type: research
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