Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is  associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

In this study C5aR1 –/– and C5aR2–/– mice were compared to the wild type in a renal IRI model leading to renal fibrosis. C5a receptor expression, kidney morphology, inflammation, and fibrosis were measured in different mouse strains one, seven and 21 days after IRI. Renal perfusion was evaluated by functional m agnetic resonance imaging.

Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Anja Thorenz, Katja Derlin, Christoph Schr öder, Lisa Dressler, Vijith Vijayan, Pooja Pradhan, Stephan Immenschuh, Anne Jörns, Frank Echtermeyer, Christine Herzog, Rongjun Chen, Song Rong, Jan Hinrich Bräsen, Cees van Kooten, Torsten Kirsch, Christian Tags: Basic Research Source Type: research