PD-006Characterizations of DNA copy number variations and spatio-temporal intra tumor heterogeneity in liver metastasis from colorectal cancer patients

Introduction: Metastatic colorectal cancers (mCRC) are highly heterogeneous, representing a challenge in treatment management. Studies have largely investigated the genomic landscape of primary tumors at diagnosis. As metastasis is responsible for 90% of cancer patient deaths, this highlights the need to characterize the genomic landscape of metastasis over time of treatment to decipher their evolution and role in therapeutic resistance.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research