Interferon- γ and Colorectal Cancer: an up-to date

Colorectal cancer still remains the third cause of cancer death among cancer patients. Early diagnosis is crucial and they can be either endoscopic or with blood biomarkers. Endoscopic methods consist of gastroscopy and colonoscopy, however; in recent years, endoscopic ultrasound is being used. The microenvironment is very important for the successful delivery of the treatment. Several proteins and hormones play a crucial role in the efficiency of the treatment. In the current mini review we will focus on interferon-γ.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research

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Health-Related Complications of Acromegaly—Risk of Malignant Neoplasms Marek Ruchala*† and Kosma Wolinski† Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland The issue of increased risk of benign and malignant neoplasms in patients with acromegaly remains the topic of debate from many years and was addressed by numerous studies. Many of them have shown increase in the cancer incidence. Among particular types of malignancies, thyroid, colorectal, and breast cancer are most commonly indicated as associated with acromegaly. Single ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Purpose: Residual faecal material, poor insufflation, complex diverticular disease, segmental colitis and spasm can mimic tumours on diagnostic Computed Tomography (CT). We aim to evaluate the diagnostic accuracy of focused ultrasound (US) in characterisation of colonic pathology in patients following abdominal CT and CT colonography (CTC). US is used in our service to allow patients to proceed direct to surgery without confirmatory colonoscopy.
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
We present a case of a 22-year-old female with AFAP who was treated with endoscopic polypectomy and surveilled by annual colonoscopy. Guidelines for AFAP surveillance suggest annual colonoscopy with endoscopic polypectomy in asymptomatic individuals. Indications for immediate surgery include documented or suspected cancer or significant symptoms. Preferred surgical option in AFAP is colectomy and ileo-rectal anastomosis. Surveillance of the AFAP patients should include upper GI endoscopy and duodenoscopy with random biopsies of fundic gland polyps and endoscopic resection of detected adenomas. Annual thyroid ultrasound is ...
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
The Laboratory for Advanced Medicine (LAM), a biotechnology company headquartered in the US, offers non-invasive, early stage cancer detection tests that will use the IvyGene Platform. These IvyGene tests are based on detecting genomic DNA shed by ca...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Exclusive Oncology Pathology Source Type: blogs
AbstractModern medicine provides almost infinite diagnostic and therapeutic possibilities if compared to the past. As a result, patients undergo a multiplication of tests and therapies, which in turn may trigger further tests, often based on physicians ’ attitudes or beliefs, which are not always evidence-based. The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) adhered to the Choosing Wisely Campaign to promote an informed, evidence-based approach to gastroenterological problems. The aim of this article is to report the five recommendations of the AIGO Choosing Wisely Campaign, and the p...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
CONCLUSION: Dual-energy CT demonstrated a difference in the mean atomic mass in benign colorectal tumors in comparison to malignant colorectal tumors. PMID: 30764692 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
AbstractPrimary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. The diagnosis can be confirmed via cholangiography, either magnetic resonance cholangiography (MRCP) or endoscopic retrograde cholangiography if the former is inconclusive. The clinical course is marked by progre...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
​BY ARJUN BHARADWAJ; MARGARET GAVOR, MBChB, MPH; &KHALID MALIK, MDA 65-year-old man presented to the emergency department complaining of sudden-onset left-sided abdominal pain followed by a “seizure.” His abdominal pain started a few hours prior to presentation, was sharp in nature, and radiated to his back and umbilicus. The pain waxed and waned, worsened when he walked or sat up, and at its worst was a 10/10. He took a laxative and two antacids, but received no relief.Each “seizure” episode lasted about 30 seconds and occurred every five minutes. He said he felt drained after each event but ...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
​BY GREGORY TAYLOR, DO, &DIANE KAISER, DOA 41-year-old woman presented to the emergency department with abdominal pain, noting multiple episodes over the past year of intermittent right upper quadrant pain that she described as “achy” and “fullness.” These episodes occurred sporadically with no identifiable exacerbating factors. Associated symptoms included a 20-pound unintentional weight loss over two months with occasional nausea and vomiting. She was a former smoker of 10-pack years and had stopped two months prior to arrival, and she reported drinking two to three glasses of wine a week. S...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
That statement from a recent patient was a summary to me of what is bad in our health care “system.”  It’s a terrible summary of what is seen all over this country with people who must make the choice between financial solvency and health. Here’s what happened:  It was a new patient I saw, who is a veteran who owns two businesses.  He went out on his own when he “kept getting laid off.”  He has largely been successful in what he’s doing, but as is the case with many these days, he couldn’t afford health insurance.  This was especially bad because he h...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Primary Care Public Health & Policy Source Type: blogs
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