Autophagy activation in circulating proangiogenic cells (PACs) aggravates AKI in type I diabetes mellitus.
CONCLUSION: Pharmacological autophagy activation may most likely not serve as effective strategy for improving PAC competence in diabetic AKI in general. On the contrary, several outcome parameters (excretory function, fibrosis, EndoMT) may even be worsened. PMID: 29897281 [PubMed - as supplied by publisher]
ConclusionsEosinophilic ulcer is likely a reactive painful lesion that mainly affects the tongue of adults, which may clinically mimic oral SCC.
ConclusionsChanges in oral microbiota are related to changes in the salivary pH associated with metabolic control of type 2 diabetes.
A 70-year-old female patient was referred to the stomatology clinic for evaluation of an injury on her tongue. On medical history, it was found she was a patient with type 2 diabetes mellitus and hypertension, using antihypertensive, hypoglycemic, and antihistamine agents along with insulin, eye drops, and sedatives. She was also being seen by an endocrinologist. She is allergic to many medications (acetylsalicylic acid and its derivatives, dipyrone, and nonsteroidal anti-inflammatory drugs). On oral examination, the patient had a dry oral mucosa with little lubrication and mild candidosis of the tongue, treated by ketoconazole.
Myiasis is a disease caused by the invasion of tissues by the larvae of flies. Herein, we present 2 cases of this disease. Case 1: a 47-year-old male patient with diabetes mellitus, hypertension, malnutrition, and mental disorders was hospitalized for sequelae of stroke. The intraoral examination revealed poor hygiene and the presence of an ulcerated lesion with a whitish border in the left upper lip mucosa showing larvae with wriggling movement. Case 2: an 11-year-old male patient diagnosed with cerebral palsy and West syndrome.
A 56-year-old white woman complained of "bleeding gum lesions." Previous medical history revealed systemic arterial hypertension, diabetes mellitus, cardiac arrhythmia, and surgery for a prosthetic heart valve placement. Oral examination showed 3 pedunculated nodules in the gingiva involving the 3 remaining upper teeth, about 1.5 cm in greatest diameter, with rapid growth and bleeding but otherwise asymptomatic. Diagnostic hypothesis was pyogenic granuloma. Complete blood count showed leukopenia and thrombocytopenia.
A 49-year-old woman was referred to the clinic complaining of "gum pain." Anamnesis revealed chronic smoking for 32 years, diabetes mellitus, and renal lithiasis. Extraoral examination was irrelevant. Intraoral examination revealed ulcerated exophytic growth in the edentulous region corresponding to the inferior incisors, covered by pseudomembrane, firm to palpation, with irregular borders and contours, approximately 1.5 cm in diameter, and with about 2 months of evolution. The onset occurred after extraction of the lower incisors.
A male patient, 72 years of age and white, complained of "bubbles in the mouth for 10 days." Past medical history: Received renal transplant (2001), diabetes mellitus, coronary artery bypass graft, and radiation therapy for basal cell carcinoma in the head region (2014). Extraoral examination showed basal cell carcinomas in the right and left ears and blood lesions in the arms. At intraoral examination, we observed hemorrhagic blister and ulcerated lesion with superficial shallow edges, preceded by blister both in the lower lip mucosa, blood injury, slightly high edges, blackish coloration, and located in the mucosa of the cheek.
To determine number and species of Candida present in saliva according to the glycated hemoglobin (HbA1c) values and salivary pH in patients with type 2 diabetes mellitus (DM2).