TBI: To Be (Irradiated) or not to be? That remains the question

The feasibility and success of allogeneic hematopoietic cell transplantation (HCT) was first reported by Thomas and colleagues over 40 years ago using lethal doses of total body irradiation (TBI) and high dose cyclophosphamide (Cy) to eradicate acute leukemia with subsequent reconstitution of marrow function.1 Although these high doses of TBI may have reduced the risk of relapse,2 it was offset by excessively high treatment-related mortality (TRM) (>50%), with both immediate and long-term post-transplant complications.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research