Malaria-Free Paraguay; Don't Neglect Nipah Virus; Global Penicillin Shortage?

(MedPage Today) -- News and commentary from the world of infectious diseases
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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This report shares key lessons learned for community engagement practices during a malaria outbreak response in the Los Tres Brazos neighborhood of urban Santo Domingo, Dominican Republic from 2015-2016. In this two-year period, 233 cases of malaria were reported-more than seven times the number of cases (31) reported in the previous two years. The initial outbreak response by the national malaria program emphasized "top-down" interventions such as active surveillance, vector control, and educative talks within the community. Despite a transient reduction in reported cases in mid-2015, transmission resurged at th...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Publication date: Available online 6 August 2020Source: Arabian Journal of ChemistryAuthor(s): Mohammad Hassan Mahmoudian, Mehdi Fazlzadeh, Maryam Hazrati Niari, Ali Azari, Eder C. Lima
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
Plasmodium vivax has the largest geographic range of human malaria species and is challenging to manage and eradicate due to its ability to establish a dormant liver stage, the hypnozoite, which can reactivate leading to relapse. Until recently, the only treatment approved to kill hypnozoites was the 8-aminoquinoline, primaquine, requiring daily treatment for 14 days. Tafenoquine, an 8-aminoquinoline single-dose treatment with activity against P. vivax hypnozoites, has recently been approved by the US Food and Drug Administration and Australian Therapeutic Goods Administration for the radical cure of P. vivax malari...
Source: Pharmacogenetics and Genomics - Category: Genetics & Stem Cells Tags: Short Communication Source Type: research
Abstract The bacterial peptidoglycan layer forms a complex mesh-like structure that surrounds the cell, imparting rigidity to withstand cytoplasmic turgor and the ability to tolerate stress. As peptidoglycan has been the target of numerous clinically successful antimicrobials such as penicillin, the biosynthesis, remodeling and recycling of this polymer has been the subject of much interest. Herein, we review recent advances in the understanding of peptidoglycan biosynthesis and remodeling in a variety of different organisms. In order for bacterial cells to grow and divide, remodeling of cross-linked peptidoglycan...
Source: Advances in Applied Microbiology - Category: Microbiology Authors: Tags: Adv Appl Microbiol Source Type: research
Purpose of review To highlight the lessons learned from the Ebola outbreak that may inform our approach to the COVID-19 pandemic, particularly related to the widespread disruption of healthcare, ophthalmic disease manifestations, and vision health systems strengthening for future outbreaks. Recent findings Coronavirus disease 2019 (COVID-19), first detected in China in December 2019, has become a worldwide health emergency, with significant disruption of all aspects of society, including travel, business, and medical care. Although this pandemic has had unprecedented effects on healthcare delivery in the United States...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: COVID19: Edited by Allen Chiang and Prithvi Mruthyunjaya Source Type: research
Authors: Varo R, Balanza N, Mayor A, Bassat Q Abstract INTRODUCTION: Malaria continues to be a major global health problem, with over 228 million cases and 405,000 deaths estimated to occur annually. Rapid and accurate diagnosis of malaria is essential to decrease the burden and impact of this disease, particularly in children. We aimed to review the main available techniques for the diagnosis of clinical malaria in endemic settings and explore possible future options to improve its rapid recognition. AREAS COVERED: literature relevant to malaria diagnosis was identified through electronic searches in Pubmed, w...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Publication date: 25 September 2020Source: International Journal of Pharmaceutics, Volume 587Author(s): Megha Marwah, Pratik Narain Srivastava, Satish Mishra, Mangal Nagarsenker
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ord M Abstract The anti-malarial drug Chloroquine (CQ) and its derivative hydroxychloroquine have shown antiviral activities in vitro against many viruses, including coronaviruses, dengue virus and the biosafety level 4 Nipah and Hendra paramyxoviruses. The in vivo efficacy of CQ in the treatment of COVID-19 is currently a matter of debate. CQ is a lysosomotrophic compound that accumulates in lysosomes, as well as in food vacuoles of Plasmodium falciparum. In the treatment of malaria, CQ impairs the digestion and growth of the parasite by increasing the pH of the food vacuole. Similarly, it is assumed that the ant...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
Suddenly the corner of the world map occupied by Asia, formerly painted monochrome, is transformed into a multidimensional colour display with society, culture, economy, and politics as its axes. This display vividly shows how epidemics of infectious diseases, such as plague, malaria, and cholera, as well as the more recent severe acute respiratory syndrome, Nipah virus, and Zika virus outbreaks, contributed —or continue to contribute—to shaping the process of modernisation in Asia, especially east Asia.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Media Watch Source Type: research
More News: Infectious Diseases | Malaria | Nipah Virus | Paraguay Health | Penicillin | Primary Care