Development of a Standardized Cranial Phantom for Training and Optimization of Functional Stereotactic Operations

Conclusions: This cranial phantom is a simple and effective model to simulate functional and stereotactic neurosurgical operations. This might be useful for teaching and training of neurosurgeons, establishing operations in a new center and for optimization of radiological examinations.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research

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We present a technical development in the dynamic causal modelling of electrophysiological responses that combines qualitatively different neural mass models within a single network. This affords the option to couple various cortical and subcortical nodes that differ in their form and dynamics. Moreover, it enables users to implement new neural mass models in a straightforward and standardized way. This generic framework hence supports flexibility and facilitates the exploration of increasingly plausible models. We illustrate this by coupling a basal ganglia-thalamus model to a (previously validated) cortical model develop...
Source: NeuroImage - Category: Neuroscience Source Type: research
Human Brain Mapping, EarlyView.
Source: Human Brain Mapping - Category: Neurology Authors: Source Type: research
Performed as one of the major treatments for advanced Parkinson's disease (PD), deep brain stimulation (DBS) surgery can induce adverse effects (AEs) on cognition, gait, mood, speech and swallowing, which are frequently reported and seriously affect the patient's daily life.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
The pilot study of Alzheimer's patients found that deep brain stimulation targeting frontal brain regions can reduce the overall performance decline typically seen in people with mild Alzheimer ’ disease.ByAlzheimer's Reading RoomWhile most treatments for Alzheimer ’s disease focus on improving memory, researchers atThe Ohio State University Wexner Medical Center conducted a studyaimed at slowing the decline of problem solving and decision-making skills in these patients.Thin electrical wires were surgically implanted into the frontal lobes of the brains of patients with Alzheimer ’s disease to determine ...
Source: Alzheimer's Reading Room, The - Category: Neurology Source Type: blogs
Merchant et al. propose a computerized spiral analysis test for differentiation of essential tremor (ET) patients who develop “early tolerance” to deep brain stimulation (DBS) benefits (within two years) from those who exhibit sustained improvements (Merchant et al., 2018). In their study, ET patients were identified to develop “early tolerance” if they had a higher degree of severity score and a greater loop-to-lo op width variability index on spiral drawings. The latter characteristic is usually observed in patients with underlying cerebellar dysfunction.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Letter to the Editor Source Type: research
ConclusionDBS is a safe surgical option for patients with various neurological and movement disorders. Although the risk of ICH is low, delayed hemorrhages are possible and can be a devastating complication all clinicians must be aware of and be prepared for in order to better manage and treat patients.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
ConclusionThe detailed surgical procedure of slMFB DBS implantation has not been described before. The slMFB emerges as an interesting region for the treatment of major depression (and other psychiatric diseases) with DBS. So far it has only been successfully researched in open label clinical case series and in 15 patients published. Stimulation probably achieves its effect through direct white-matter modulation of slMFB fibers. The surgical implantation comprises a standardized protocol combining tractographic imaging based on DTI, targeting and electrophysiological evaluation of the target region. To this end, slMFB DBS ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
AbstractThis contribution intends to explore patients ’ lived experience, with a focus on the temporal dimension. On the basis of a qualitative study that led me to interview persons with Parkinson’s disease (PD), caregivers, and medical professionals, I develop an empirical and philosophical investigation of the temporalities surrounding the imple mentation of deep brain stimulation (DBS) in Greece. I raise the issue of access to DBS medical care, and show how distinct temporalities are implied when the patients face such a matter: that of linear time, linked with the medical discourse, the bureaucratic time l...
Source: Medicine, Health Care and Philosophy - Category: Medical Ethics Source Type: research
We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1 MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0.70 mm, a detection threshold of 1.75 mA at 1 MPa and a sensitivit...
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
During the past two decades, deep brain stimulation (DBS) has been recognized as an efficient therapy that alleviates the symptoms of various treatment-resistant movement disorders such as Parkinson ’s disease (PD), dystonia, and tremor (Lyons, 2011; Vidailhet et al., 2013; Aviles-Olmos et al., 2014; Fasano et al., 2014; Kalia et al., 2013; Larson, 2014). Recent reports suggest that DBS can also be effective for treating psychiatric disorders such as depression, obsessive-compulsive disorder, Tourette’s syndrome (Holtzheimer and Mayberg, 2011) as well as dementia-related disorders and Alzheimer’s disease ...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
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