Development of a Standardized Cranial Phantom for Training and Optimization of Functional Stereotactic Operations

Conclusions: This cranial phantom is a simple and effective model to simulate functional and stereotactic neurosurgical operations. This might be useful for teaching and training of neurosurgeons, establishing operations in a new center and for optimization of radiological examinations.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research

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Conditions:   Alzheimer Disease;   Dementia, Alzheimer Type;   Deep Brain Stimulation Interventions:   Device: Deep brain stimulation;   Drug: Best medical treatment for Alzheimer's disease Sponsors:   Buddhist Tzu Chi General Hospital;   Beijing Tiantan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Tourette Syndrome Intervention:   Device: Bilateral Deep brain stimulation of the thalamus, Medtronic Device Sponsors:   University of Cologne;   German Research Foundation Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alzheimer Disease;   Dementia, Alzheimer Type;   Deep Brain Stimulation Interventions:   Device: Deep brain stimulation;   Drug: Best medical treatment for Alzheimer's disease Sponsors:   Buddhist Tzu Chi General Hospital;   Beijing Tiantan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 21 May 2019Source: Brain StimulationAuthor(s): Hu Liang Low, Sian K. Alexander, Anjum Misbahuddin, Godfrey T. Gillett
Source: Brain Stimulation - Category: Neurology Source Type: research
Authors: Shpiner DS, Bette S, Di Luca DG, Margolesky J Abstract INTRODUCTION: For patients with Parkinson's disease (PD), the treatment of motor and nonmotor fluctuations is tantamount to maintaining quality of life. Subcutaneous apomorphine has been the only commercially available rescue therapy for the treatment of OFF episodes. In December 2018, CVT-301 (Inbrija), an inhaled formulation of LD, was approved by the FDA for this indication. Areas covered: In this review the authors summarize the armamentarium available to address motor fluctuations in PD, including medications in development. The authors discuss the p...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Around 300 million individuals are affected by major depressive disorder (MDD) in the world. Despite this high number of affected individuals, more than 50% of patients do not respond to antidepressants approved to treat MDD. Patients with MDD that do not respond to 2 or more first-line antidepressant treatments are considered to have treatment-resistant depression (TRD). Animal models of depression are important tools to better understand the pathophysiology of MDD as well as to help in the development of novel and fast antidepressants for TRD patients. This review will emphasize some discovery strategies for TRD from stu...
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson's disease, medically intractable essential tremor, and complicated segmental and generalized dystonia. In addition to accurate electrode placement in the target area, effective programming of DBS devices is considered the most important factor for the individual outcome after DBS. Programming of the implanted pulse generator (IPG) is the only modifiable factor once DBS leads have been implanted and it becomes even more relevant in cases in which the electrodes are located at the border of the intended target structure and when ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Wilson ’s disease (WD) is an autosomal recessive disorder of copper metabolism associated with ATP7B gene mutations. In this condition, copper accumulates in various tissues especially the brain, and liver. The resulting cellular dysfunction commonly manifests as ataxia, tremor, dystonia and parkinsonism . Whilst copper chelation therapies, including trientene and penicillamine, are well-established disease-modifying treatments, up to 50% of patients have persistent neurological symptoms despite optimal non-surgical therapy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism associated with ATP7B gene mutations. In this condition, copper accumulates in various tissues especially the brain, and liver. The resulting cellular dysfunction commonly manifests as ataxia, tremor, dystonia and parkinsonism. Whilst copper chelation therapies, including trientene and penicillamine, are well-established disease-modifying treatments, up to 50% of patients have persistent neurological symptoms despite optimal non-surgical therapy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Authors: Niranjan A, Raju SS, Lunsford LD Abstract Tremor is the most prevalent movement disorder in adults. Patients who are refractory to medical management can explore surgical intervention. Deep-brain stimulation (DBS) and radiofrequency thalamotomy (RFT) are surgical procedures for intractable tremor that target the ventralis intermedius (VIM) nucleus to relieve contralateral tremor. For patients who are not candidates for surgical procedures, stereotactic radiosurgery (SRS) is a minimally invasive management option for tremor relief. SRS has been used for the elderly, those considered high surgical risk for o...
Source: Progress in Neurological Surgery - Category: Neurosurgery Tags: Prog Neurol Surg Source Type: research
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