Nrf2-activated Expression of Sulfiredoxin Contributes to Urethane-induced Lung Tumorigenesis

In this study, we found that cigarette smoke condensate and urethane significantly stimulated the expression of sulfiredoxin (Srx) at the transcript and protein levels in cultured normal lung epithelial cells, and such stimulation was mediated through the activation of nuclear related factor 2 (Nrf2). To study the role of Srx in lung cancer development in vivo, mice with Srx wildtype, heterozygous or knockout genotype were subjected to the same protocol of urethane treatment to induce lung tumors.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research