Hesperidin inhibits insulin-induced phosphoinositide 3 & #8211;kinase/Akt activation in human pre-B cell line NALM-6
Conclusion: The results of this study demonstrated that cytotoxic and proapoptotic actions of hesperidin are partly mediated through the suppression of PI3K3/Akt/IKK signaling pathway. So, hesperidin might act as a chemotherapeutic agent by targeting cell survival pathways.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Roghayeh Shahbazi Makan Cheraghpour Reza Homayounfar Maryam Nazari Javad Nasrollahzadeh Sayed Hossein Davoodi Source Type: research