Population Pharmacokinetic Analysis and Model-Based Simulations of Aripiprazole for a 1-Day Initiation Regimen for the Long-Acting Antipsychotic Aripiprazole Lauroxil

ConclusionsModel-based simulations demonstrate that the 1-day initiation regimen is suitable for starting treatment with all AL doses, allowing a window of ≤ 10 days between initiation and AL administration. ALNCD may also be used to re-establish concentrations associated with therapeutic doses of AL in conjunction with a delayed AL dose.

http://link.springer.com/10.1007/s13318-018-0488-4

Source: European Journal of Drug Metabolism and Pharmacokinetics - June 11, 2018 Category: Drugs & Pharmacology Source Type: research