Supermolecular drug challenge to overcome drug resistance in cancer cells.
In this study, it is shown that the excellent efficacy and sustainability of anti-MDR is due to a stable ES complex because of the allosteric facilities of artificial enzymes when they are used as supramolecular complexes. The allosteric effect of supermolecular drugs can be explained by the induced-fit model and can provide stable feedback control systems through the loop transfer function of the Hill equation.
PMID: 29879476 [PubMed - as supplied by publisher]
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Onishi Y, Eshita Y, Ji RC, Kobayashi T, Onishi M, Mizuno M, Yoshida J, Kubota N Tags: Drug Discov Today Source Type: research