Racial Gaps Persist in ALD Patients Eligible for Transplant

(MedPage Today) -- Disparities found regarding liver transplant, mortality
Source: MedPage Today Public Health - Category: American Health Source Type: news

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AbstractBackground and aimsDoubts have been raised about efficacy of New Wilson ’s index (NWI) in predicting Liver Transplant (LT) or mortality in decompensated Wilson Disease (WD) patients. APASL ACLF Research Consortium (AARC) has introduced a new score (AARC-ACLF) which has not been studied in children.MethodsData of all pediatric WD cases were prospectively collected and analyzed. Cox regression and Area Under Receiver Operative Curve (AUROC) analyses were used to identify best predictive score for mortality at 90  days.ResultsSixty-six confirmed cases of decompensated WD, 39 (59%) improved on medical manage...
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Conditions:   Liver Failure;   Liver Transplant; Complications Intervention:   Behavioral: remote home monitoring Sponsor:   University of Cincinnati Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONTo the best of our knowledge, this is the first report of such HV reconstruction in combination with extracorporeal resection of huge liver cancer in updated world literature.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Congenital hepatic fibrosis (CHF) is a rare genetic liver disease (1/20,000 births) characterized by ductal plate malformation during bile duct development and progressive hepatic fibrosis, and is often associated with autosomal recessive polycystic kidney disease.[1] Liver transplantation is necessary for the treatment of progressive CHF patients with a severe phenotype. There are several pathological evidences to indicate that the mechanism of fibrosis in CHF is quite different from liver cirrhosis due to chronic hepatitis: hepatic fibrosis in CHF patients lacks necroinflammatory changes of hepatocytes and the activation...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
ConclusionLDLT can be undertaken in children with body weight
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 15 March 2019Source: The Annals of Thoracic SurgeryAuthor(s): Alan S. Chou, Andreas Habertheuer, Amanda L. Chin, Ibrahim Sultan, Prashanth VallabhajosyulaAbstractBackgroundPrior single-center studies suggest kidney and liver allografts are immunoprotective toward transplanted hearts. The broader effects of simultaneous transplantation of kidney or liver on protection from rejection are unclear.MethodsThe United Network for Organ Sharing database for heart transplantation was queried from 1987 to 2015 and stratified into patients undergoing heart-liver (HLT; n=192), heart-kidney (HKT; n=11...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS Low-dose steroid therapy was effective and safe for treating hyperbilirubinemia caused by early graft dysfunction, and it improved liver function. PMID: 30870403 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, BAT is a protective organ or tissue against HCC, and BACs may be a potential therapeutic tool for the treatment of HCC. PMID: 30867750 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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